Adrenalmax by Metabolics – the supplement targeting stress

Adrenalmax is a dietary supplement created and manufactured by Metabolics in the UK, specifically designed to target the symptoms of stress.

The Adrenal glands are two small walnut sizes glands that lie just above the kidneys. They are of vital importance as they deal with stress, which we are continually exposed to in today’s modern life: whether it be emotional, due to work or relationships; biochemical, due to toxicities, infections, chronic allergies or temperature change; physical, due to injury and exercise; or even down the common causes of poor sleep and poor diet and nutrition.

The adrenals produce over 50 hormones including adrenalin, noradrenalin, and the steroid hormones, glucocorticoids and mineralocorticoids.

  • Adrenalin raises the heart rate, resulting in that “nervous” feeling
  • Glucocorticoids, including cortisol, help stabilise your blood sugar and help your body convert food to energy
  • Mineralocorticoids, including aldosterone, maintain a normal blood pressure and volume by balancing sodium and potassium

The adrenals are poised for the “fight or flight” response and these three groups of hormones act together to increase your heart rate and blood flow to your muscles and brain while slowing down the digestion so that you can prepare to run or fight!

Initially, under stress the adrenals produce more hormones to compensate (this is called Hyperadrenia); but over time they struggle to keep up and go into a state of exhaustion. Symptoms can include:

  • Extreme tiredness and weakness, poor quality of sleep, exhaustion upon waking, irritability, depression, and poor concentration and memory
  • An impaired immune system, resulting in recurrent infections
  • Cravings for salty foods, caffeine, fatty foods or sugars, to gain a “quick fix”
  • Dizziness on getting up quickly, as blood pressure cannot compensate fast enough for the change in position (due to low aldosterone)
  • The need to get up at night to urinate
  • Experience of hormonal imbalances, including an increase in PMT symptoms and reduced libido
  • Weight gain due to high cortisol: this will convert proteins to glucose that then becomes additional fuel. This causes an increase in blood sugar levels and a rise in blood pressure. As blood sugar levels rise the unused glucose is stored as fat once the stress is over, resulting in weight gain, particularly abdominal fat.

The key ingredients of Adrenalmax are:

  • L Glutamine
  • Magnesium Citrate
  • Betaine
  • Olive Leaf
  • Green Tea
  • L Theanine
  • L Taurine

Founded in 1993, Metabolics supplies nutritional supplements to a global client base of practitioners in a wide range of healthcare disciplines. Popular in the UK, US, Ireland and across Europe, Metabolics also has distributors in Greece, Singapore and Australia. In total, the company receives regular orders from over 20 countries around the world.

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Editorial contact:

Emma De Maio
Tel: 07921 160 134

Editors Notes

L Glutamine:

  • An amino acid, converted to glutamic acid, which, along with glucose, is essential fuel for brain cells and their normal functioning
  • Promotes a healthy digestive tract. Adrenal exhaustion is associated with chronic fungal or parasitic infections
  • Stress and injury cause muscles to release glutamine into the blood stream and up to a third of glutamine present may be released, resulting in skeletal muscle loss if not replenished
  • Glutamine decreases sugar and alcohol cravings which the person suffering with adrenal exhaustion may be suffering from
  • As there is an inverse relationship between the adrenals and the thymus (the more stress hormones produced, the more suppressed the immune response from the thymus), the inclusion of glutamine is important to optimise immune function as the high cortisol levels, in the initial stages of stress will lower stored glutamine
  • Needed to support a division of immune cells and help white blood cells produce compounds to fight pathogens. Researchers have demonstrated that L Glutamine is decreased in over-trained athletes and after long term exercise contributing to fatigue

Magnesium citrate:

  • It’s been said that 80% of the world’s population is deficient in Magnesum (Sherry Rogers, M.D in International Medicine World Report 1992). Magnesium deficiency is prevalent in psychiatric disorders such as anxiety, agitation and panic attacks
  • Stressed adrenals often precede depression and mood disorders. Under adrenal stress, there is an increased urinary loss of Magnesium; the body having difficulty retaining Magnesium
  • Work with athletes has demonstrated that stress caused by physical exercise is capable of producing magnesium deficit, reducing physical performance and in particular, the efficiency of energymetabolism. Simple oral supplementation improved performance.
  • Magnesium is vital in the production and storage of energy within the cells. If Magnesium is lacking, potassium will be lost rapidly from the body, causing more fatigue and weakness.

Betaine (Trimethylglycine):

  • Important in the synthesis of the neurotransmitters dopamine and serotonin, which control our mood. Without dopamine, people feel unmotivated, fatigued and depressed. When dopamine is released we feel happy and experience pleasure so it is vitally important to have enough Betaine to allow the formation of Dopamine to replace the fatigue
  • A sufferer of adrenal syndrome will crave alcohol, sugar and caffeine. These all deplete the brain of dopamine furthering the need for Betaine
  • Betaine is also a cofactor in methylation, required for synthesising serotonin, which also contributes to feelings of well-being and happiness. Methylation is required for the biosynthesis of Coenzyme Q10, the prime function of which is to produce energy

Olive Leaf:

  • Oleuropeins have been shown to increase adrenaline production and enhance thermogenesis (where the body generated heat from metabolism of fat cells), outcomes which may potentially support adrenal fatigue syndrome. It does this by increasing a certain “uncoupling “protein in brown fat cells

Green Tea:

  • Not only is EGCG (epigallocatechin - the active polyphenol in Green Tea) , a potent free radical scavenger. Its benefit in this formulation is that, as a polyphenol, its main pathway of conferring effects seems to be by sending messages to our genes to either create more antioxidants or alter its response to environmental stress
  • It plays a key role in immune function, regulating T cells as a DNA methyltransferase inhibitor; remember, immune system is depressed with high cortisol

L Theanine:

  • This is an amino acid found in tea, included for its effect of diminishing fatigue
  • L Theanine can cross the blood brain barrier and increase GABA and Dopamine; both having relaxing, mood enhancing effects and creating a sense of well being
  • It’so been shown that it may help reduce blood pressure and promote concentration
  • It works antagonistically against high doses of caffeine: adrenals-stressed people are more likely to crave coffee

L Taurine:

  • Animal studies indicate that taurine antagonises the stress induced elevation of blood sugar by reducing adrenalin output from the adrenal gland
  • Oral administrations of taurine prevented the stress-induced decline of adrenaline in the adrenal gland. The stress-induced elevation of the blood level of corticosterone was not affected by taurine administration
  • Taurine is found in higher concentrations in the retina, adrenals, heart and spleen. Studies suggest that it lowers blood pressure and calms the sympathetic nervous system, which is often over active in people suffering chronic stress

Vitamin B12 (Methylcobalamin):

  • B12 helps in the formation of red blood cells, for better oxygen utilization for neurological function and DNA synthesis
  • It helps with energy production by breaking down fat and protein
  • Symptoms of B12 deficiency are tiredness and lethargy
  • B12 functions as a ‘methyl donor’; a compound that carries and donates methyl groups (a molecule of one carbon and 3 hydrogen molecules) to other molecules, including the components of cell membranes and importantly neurotransmitters. Vitamin B12 plays an important role in correct energy metabolism, immune function and nerve function
  • It is also important in homocysteine metabolism. An interaction between adrenals/pituitary and ovaries as a result of a B12 deficient diet showed an action site at the pituitary/hypophyseal axis

Metabolics - Backgrounder

Formed in 1993, Metabolics is the UK’s premium quality supplement manufacturer. Popular in the UK, US, Ireland and across Europe, Metabolics also has distributors in Greece, Singapore and Australia. In total, the company receives regular orders from over 20 countries around the world.

Unlike many suppliers who bottle and market products manufactured overseas, Metabolics manufactures its supplements at its UK facility which was upgraded in 2011 to comprise state-of-the-art pharmaceutical clean room equipment.

Metabolics is one of very few manufacturers in the world that does not use binders, hidden fillers or flowing agents (machine lubricants) such as magnesium stearate during their production processes. Although these allow manufacturers to produce a low cost product, Metabolics believes that they compromise the quality of the supplement. Similarly, Metabolics only uses the best possible ingredients.

Manufacturing in the UK enables Metabolics to control and maintain their quality standards. The company is a comparatively small-volume manufacturer that manufactures on demand rather than producing large quantities of stock. This means that, as scientific knowledge of nutrition evolves, Metabolics can respond quickly with new product ranges.  This allows them to maintain their commitment to producing products which best reflect the latest scientific research.

Owned and run by original founder, Alison Astill-Smith, Metabolics has a dedicated workforce and enjoys a very low turnover of staff.  The company has ISO:9001 as well as ISO:14001 accreditation.  These standards recognise Metabolics’ quality management system and commitment to a pro-active environmental policy.

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