Metabolics Acetyl L Carnitine & Alpha Lipoic Acid – fighting an age old problem

Acetyl L Carnitine & Alpha Lipoic Acid, created and manufactured in the UK by Metabolics, provide two of the most widely investigated epigenetic modifiers.

Epigenetics is the study of how environmental factors, such as diet, stress, exercise and toxins, can modify our genes throughout our lives. Research has demonstrated that acetyl-L-carnitine and lipoic acid have positive epigenetic effects, particularly in reducing the signs of aging.

Metabolics Acetyl-L-carnitine and alpha lipoic acid have been shown to reduce damage to mitochondria, the part of a cell which produces energy and is thought to be compromised in aging. Research findings published in the US journal, Proceedings of the National Academy of Science (PNAS), in 2002 describes how aged rats were given oral acetyl-L-carnitine and lipoic acid. As well as reducing mitochondrial aging in the rats’ brains, the supplementation reversed the already present signs of aging.

Reviewing these findings, scientists at Oregon State University suggested that acetyl-L-carnitine and alpha lipoic acid could also provide protection and reverse age-related changes in the heart. They also stated that acetyl-L-carnitine and alpha lipoic acid are most effective when used together.

Acetyl-L-carnitine has been shown to reduce pain in a variety of animal models. Research published in Molecular Pharmacology in 2002 showed that acetyl-L-carnitine in rats altered the DNA in the spinal cord cells by increasing the production of mGlu2 receptors, which are important in pain relief.

A study in 2004, published in PNAS, focused on the epigenetic mechanisms of lipoic acid. Investigating the role of lipoic acid in rat’s livers, scientists analysed the genetic upregulation in the liver and showed that the supplement increases the genetic expression of Nrf2, an enzyme which produces the protective antioxidant, glutathione. The group hypothesised that aging in the liver is due to loss of Nrf2 expression and that lipoic acid supplementation reverses this loss by altering the expression of the Nrf2 gene.

Research into the effect of acetyl L carnitine in humans is also promising. In a study in Italy among 481 people, acetyl L carnitine significantly reduced signs of dementia, including memory loss, depression and mental decline. The effects were maintained 30 days after the treatment was stopped.

Metabolics Acetyl L Carnitine & Alpha Lipoic Acid is one of the four components in the Metabolics Epigenetic Support Pack.

Each capsule of Metabolics Acetyl L Carnitine & Alpha Lipoic Acid contains:

acetyl L carnitine - 250mg

alpha lipoic acid - 250mg

Metabolics Acetyl L Carnitine & Alpha Lipoic Acid is available online at £60.53 per 60 capsule pot.

Founded in 1993, Metabolics supplies nutritional supplements to a global client base of practitioners in a wide range of healthcare disciplines. The company has distributors in Europe, Asia and Australia and receives regular orders from 22 countries including Russia and the USA.

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Editorial contacts:

 Emma De Maio                               
Tel 07921 160 134



Formed in 1993, Metabolics is the UK’s premium quality supplement manufacturer. Popular in the UK, US, Ireland and across Europe, Metabolics also has distributors in Greece, Singapore and Australia. In total, the company receives regular orders from over 20 countries around the world.

Unlike many suppliers who bottle and market products manufactured overseas, Metabolics manufactures its supplements at itsUKfacility which was upgraded in 2011 to comprise state-of-the-art pharmaceutical clean room equipment.

Metabolics is one of very few manufacturers in the world that does not use binders, hidden fillers or flowing agents (machine lubricants) such as magnesium stearate during their production processes. Although these allow manufacturers to produce a low cost product, Metabolics believes that they compromise the quality of the supplement. Similarly, Metabolics only uses the best possible ingredients.

Manufacturing in theUKenables Metabolics to control and maintain their quality standards. The company is a comparatively small-volume manufacturer that manufactures on demand rather than producing large quantities of stock. This means that, as scientific knowledge of nutrition evolves, Metabolics can respond quickly with new product ranges.  This allows them to maintain their commitment to producing products which best reflect the latest scientific research.

Owned and run by original founder, Alison Astill-Smith, Metabolics has a dedicated workforce and enjoys a very low turnover of staff.  The company has ISO:9001 as well as ISO:14001 accreditation.  These standards recognise Metabolics’ quality management system and commitment to a pro-active environmental policy.

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