DEALING BY DIRECTORS COMPANIES ACT 1985 SECTIONS 324/329

Transaction by Persons Discharging Managerial Responsibilities
Disclosure Rules DR 3.1.2R

We hereby inform you that on 23 February 2007, the following Directors acquired an interest in the USD0.25 Ordinary Shares of AstraZeneca PLC. The interest arises as a result of the previously disclosed arrangements relating to the payment of annual bonuses for 2006 whereby each individual is required to defer a portion of the bonus earned into shares for a period of three years. The shares were allocated at a price of 2911 pence per share. The individuals will become beneficially entitled to these shares on 24 February 2010.

Name Number of shares allocated Total interest in shares after this allocation Percentage of shares in issue
J R Symonds 6,491 114,921 0.008%
J S Patterson 5,600 94,502 0.006%



G H R Musker
COMPANY SECRETARY

About Us

AstraZeneca is a global, innovation-driven biopharmaceutical business with a primary focus on the discovery, development and commercialisation of prescription medicines. As a leader in gastrointestinal, cardiovascular, neuroscience, respiratory and inflammation, oncology and infectious disease medicines, AstraZeneca generated global revenues of US $32.8 billion in 2009. For more information please visit: www.astrazeneca.com

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