Director/PDMR Shareholding

Transaction by Person Discharging Managerial Responsibilities
Disclosure Rule DTR 3.1.4

On 1 August 2016, the interest of Marc Dunoyer, a person discharging managerial responsibilities, in the ordinary shares of AstraZeneca PLC changed as detailed below.

The change in interest relates to the vesting of awards of shares made in August 2013 under the AstraZeneca Performance Share Plan and the AstraZeneca Restricted Share Plan.

Following the application of performance measures specified at the time of grant, Mr Dunoyer has become beneficially entitled to 78% of the shares originally awarded. In accordance with the plan rules, any unvested part of the award has immediately and irrevocably lapsed.

After sufficient vested shares were withheld to satisfy certain tax obligations arising on the vesting, Mr Dunoyer has become beneficially entitled to and has received 43,730 shares into a personal brokerage account.

For tax purposes, the fair market value of the shares at vest was 5048 pence per share being the closing price of AstraZeneca ordinary shares on the last trading day preceding the vesting day.

The attached notification, made in accordance with the requirements of the EU Market Abuse Regulation, gives further detail.

Notification and public disclosure of transactions by persons discharging managerial responsibilities and persons closely associated with them

1 Details of the person discharging managerial responsibilities / person closely associated
a) Name Marc Dunoyer
2 Reason for the notification
a) Position/status Chief Financial Officer
b) Initial notification /Amendment Initial notification
3 Details of the issuer, emission allowance market participant, auction platform, auctioneer or auction monitor
a) Name AstraZeneca PLC
b) LEI Not applicable
4 Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each type of transaction; (iii) each date; and (iv) each place where transactions have been conducted
a) Description of the financial instrument, type of instrument Identification code Ordinary Shares of US$0.25 each in AstraZeneca PLC GB0009895292
b) Nature of the transaction Acquisition of Ordinary Shares pursuant to a vesting of awards under the AstraZeneca Performance Share Plan and the AstraZeneca Restricted Share Plan
c) Price(s) and volume(s)  Price(s) Volume(s)
5048 pence 43,730
d) Aggregated information - Aggregated volume - Price Not applicable - single transaction
e) Date of the transaction 1 August 2016
f) Place of the transaction London

A C N Kemp

Company Secretary

1 August 2016

About Us

AstraZeneca is a global, innovation-driven biopharmaceutical business with a primary focus on the discovery, development and commercialisation of prescription medicines. As a leader in gastrointestinal, cardiovascular, neuroscience, respiratory and inflammation, oncology and infectious disease medicines, AstraZeneca generated global revenues of US $32.8 billion in 2009. For more information please visit: www.astrazeneca.com

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