Director/PDMR Shareholding

Transaction by Person Discharging Managerial Responsibilities

Disclosure Rule DTR 3.1.4

On 30 June 2014, Pascal Soriot, a Director of the Company, notified us that, on 30 June 2014, he purchased 46,200 AstraZeneca PLC Ordinary Shares of $0.25 each at a price of 4345 pence per share.

A C N Kemp

Company Secretary

1 July 2014

About Us

AstraZeneca is a global, innovation-driven biopharmaceutical business with a primary focus on the discovery, development and commercialisation of prescription medicines. As a leader in gastrointestinal, cardiovascular, neuroscience, respiratory and inflammation, oncology and infectious disease medicines, AstraZeneca generated global revenues of US $32.8 billion in 2009. For more information please visit: