Director/PDMR Shareholding

Transaction by Person Discharging Managerial Responsibilities

Disclosure Rule DTR 3.1.4

On 1 August 2014, Bruce Burlington, a Director of the Company notified us that, on 1 August 2014, he purchased 500 AstraZeneca American Depositary Shares (ADSs) at a price of $72.71 per ADS.

One AstraZeneca ADS equals one AstraZeneca PLC Ordinary Share of $0.25.

A C N Kemp

Company Secretary

4 August 2014

About Us

AstraZeneca is a global, innovation-driven biopharmaceutical business with a primary focus on the discovery, development and commercialisation of prescription medicines. As a leader in gastrointestinal, cardiovascular, neuroscience, respiratory and inflammation, oncology and infectious disease medicines, AstraZeneca generated global revenues of US $32.8 billion in 2009. For more information please visit: www.astrazeneca.com

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