Director/PDMR Shareholding

Transaction by Person Discharging Managerial Responsibilities
Disclosure Rule DTR 3.1.4

On 10 November 2014, Luke Miels, EVP, Global Product and Portfolio Strategy, a person discharging managerial responsibilities, notified us that, on 7 November 2014, he purchased 10,500 AstraZeneca PLC Ordinary Shares of $0.25 each at a price of 4614.5 pence per share.

A C N Kemp
Company Secretary
10 November 2014

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AstraZeneca is a global, innovation-driven biopharmaceutical business with a primary focus on the discovery, development and commercialisation of prescription medicines. As a leader in gastrointestinal, cardiovascular, neuroscience, respiratory and inflammation, oncology and infectious disease medicines, AstraZeneca generated global revenues of US $32.8 billion in 2009. For more information please visit: www.astrazeneca.com

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