Director/PDMR Shareholding

Transaction by Persons Discharging Managerial Responsibilities

Disclosure Rule DTR 3.1.4

The following individuals, who are all Directors of the Company, have notified us that they have purchased AstraZeneca PLC Ordinary Shares of $0.25 each or AstraZeneca American Depositary Shares (ADSs).

One AstraZeneca ADS equals one AstraZeneca PLC Ordinary Share of $0.25.

Name of Director Date of notification Date of purchase Number of shares purchased Purchase price
Cori Bargmann 1 May 2015 29 April 2015 700 $69.21
Ann Cairns 1 May 2015 30 April 2015 1,100 4455p
Jean-Philippe Courtois 29 April 2015 28 April 2015 2,500 4536p

A C N Kemp

Company Secretary

1 May 2015

About Us

AstraZeneca is a global, innovation-driven biopharmaceutical business with a primary focus on the discovery, development and commercialisation of prescription medicines. As a leader in gastrointestinal, cardiovascular, neuroscience, respiratory and inflammation, oncology and infectious disease medicines, AstraZeneca generated global revenues of US $32.8 billion in 2009. For more information please visit: www.astrazeneca.com

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