Holding(s) in Company

TR-1: Standard form for notification of major holdings

NOTIFICATION   OF MAJOR HOLDINGS (to be sent to the relevant issuer and to the FCA in Microsoft Word format if possible)i
1a.   Identity of the issuer or the underlying issuer of existing shares to which   voting rights are attachedii: AstraZeneca PLC
1b. Please indicate if the issuer is a non-UK issuer  (please mark with an "X" if   appropriate)
Non-UK Issuer
2.   Reason for the notification (please mark the appropriate box or boxes with an "X")
An acquisition or disposal of voting rights X
An acquisition or disposal of financial   instruments
An event changing the breakdown of voting rights
Other (please specify)iii:
3.   Details of person subject to the notification obligationiv
Name The Capital Group Companies, Inc.   ("CGC")
City and country of registered office (if   applicable) Los Angeles, CA 90071, USA
4. Full   name of shareholder(s) (if different from 3.)v
Name
City and country of registered office (if   applicable)
5. Date   on which the threshold was crossed or reachedvi: 10 August 2017
6. Date   on which issuer notified (DD/MM/YYYY): 14 August 2017
7. Total   positions of person(s) subject to the notification obligation
% of voting rights attached to shares (total of   8. A) % of voting rights through financial instruments
  (total of 8.B 1 + 8.B 2)
Total of both in % (8.A + 8.B) Total number of voting rights of issuervii
Resulting situation on the date on which   threshold was crossed or reached 4.979% 0.000% 4.979% 1,265,794,991
Position of previous notification (if applicable) 5.001% 0.000% 5.001%

 

8.   Notified details of the resulting situation on the date on which the   threshold was crossed or reachedviii
A:   Voting rights attached to shares
Class/type of
  shares
ISIN code (if possible)
Number of voting rightsix % of voting rights
Direct(Art 9 of Directive 2004/109/EC) (DTR5.1) Indirect(Art 10 of Directive 2004/109/EC) (DTR5.2.1) Direct(Art 9 of Directive 2004/109/EC) (DTR5.1) Indirect(Art 10 of Directive 2004/109/EC) (DTR5.2.1)
Ordinary(GB0009895292) 51,247,123 4.049%
ADRs(US0463531089) 11,782,188 0.931%
SUBTOTAL 8. A 63,029,311 4.979%
B 1:   Financial Instruments according to Art. 13(1)(a) of Directive 2004/109/EC   (DTR5.3.1.1 (a))
Type of financial instrument Expiration
  date
x
Exercise/
  Conversion Period
xi
Number of voting rights that may be acquired if   the instrument is exercised/converted. % of voting rights
N/A
SUBTOTAL 8. B 1
B 2:   Financial Instruments with similar economic effect according to Art. 13(1)(b)   of Directive 2004/109/EC (DTR5.3.1.1 (b))
Type of financial instrument Expiration
  date
x
Exercise/
  Conversion Period
xi
Physical or cash settlementxii Number of voting rights % of voting rights
N/A
SUBTOTAL 8.B.2

 

9.   Information in relation to the person subject to the notification obligation (please mark theapplicable box with an "X")
Person subject to the notification obligation is   not controlled by any natural person or legal entity and does not control any   other undertaking(s) holding directly or indirectly an interest in the   (underlying) issuerxiii
Full chain of controlled undertakings through which the voting rights   and/or the
  financial instruments are effectively held starting with the ultimate   controlling natural person or legal entityxiv (please add additional rows as necessary)
X
Namexv % of voting rights if it equals or is higher than   the notifiable threshold % of voting rights through financial instruments   if it equals or is higher than the notifiable threshold Total of both if it equals or is higher than the   notifiable threshold
The Capital Group Companies, Inc. Holdings by CG Management companies are set out   below:
Capital Guardian Trust Company1
Capital International, Inc.1
Capital International Limited1
Capital International Sàrl1
• Capital Research and Management   Company2
1Indirect subsidiaries of Capital Research and   Management Company. 2Subsidiary of The Capital Group Companies, Inc.
10. In   case of proxy voting, please identify:
Name of the proxy holder
The number and % of voting rights held
The date until which the voting rights will be   held
11.   Additional informationxvi
CGC is the parent company of Capital Research and   Management Company ("CRMC").  CRMC is a U.S.-based investment   management company that manages the American Funds family of mutual   funds.  CRMC manages equity assets for various investment companies   through three divisions, Capital Research Global Investors, Capital   International Investors and Capital World Investors.  CRMC in turn is   the parent company of Capital Group International, Inc. ("CGII"),   which in turn is the parent company of five investment management companies   ("CGII management companies"): Capital Guardian Trust Company,   Capital International, Inc., Capital International Limited, Capital   International Sàrl and Capital International K.K.  The CGII management   companies primarily serve as investment managers to institutional clients.Neither CGC nor any of its affiliates own shares   of AstraZeneca PLC for its own account.  Rather, the shares reported on   this Notification are owned by accounts under the discretionary investment   management of one or more of the investment management companies described   above.

 

Place of   completion Los Angeles, CA, USA
Date of   completion 11 August 2017

About Us

AstraZeneca is a global, innovation-driven biopharmaceutical business with a primary focus on the discovery, development and commercialisation of prescription medicines. As a leader in gastrointestinal, cardiovascular, neuroscience, respiratory and inflammation, oncology and infectious disease medicines, AstraZeneca generated global revenues of US $32.8 billion in 2009. For more information please visit: www.astrazeneca.com

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