Publication of Supplementary Prospectus

Publication of Supplemental Prospectus

Following a routine technical update in June 2014 of the Company's Euro Medium Term Note ("EMTN") programme established in 2007, the following supplemental prospectus has been approved by the UK Listing Authority and is available for viewing:

Supplemental Prospectus for the AstraZeneca PLC U.S.$5,000,000,000 Euro Medium Term Note Programme (the "Supplemental Prospectus")

The Supplemental Prospectus should be read in connection with, and forms part of, the base prospectus dated 24 June 2014 prepared by the Company in connection with the EMTN programme (the "Base Prospectus").

To view the full Supplemental Prospectus, please paste the following URL into the address bar of your browser:

http://www.rns-pdf.londonstockexchange.com/rns/2358X_-2014-11-17.pdf

To view the full Base Prospectus, please paste the following URL into the address bar of your browser:

http://www.rns-pdf.londonstockexchange.com/rns/4351K_1-2014-6-24.pdf

A copy of the Supplemental Prospectus will shortly be submitted to the National Storage Mechanism and will be available for inspection at:

http://www.morningstar.co.uk/uk/NSM

A C N Kemp
Company Secretary
17 November 2014

About Us

AstraZeneca is a global, innovation-driven biopharmaceutical business with a primary focus on the discovery, development and commercialisation of prescription medicines. As a leader in gastrointestinal, cardiovascular, neuroscience, respiratory and inflammation, oncology and infectious disease medicines, AstraZeneca generated global revenues of US $32.8 billion in 2009. For more information please visit: www.astrazeneca.com

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