CLINICAL PHASE I TRIAL WITH HEPATITIS C VIRUS PROTEASE INHIBITOR INITIATED

Medivir, on behalf of the Tibotec and Medivir collaborative project, announced that this week Tibotec initiated a phase I clinical trial with a potent and selective hepatitis C virus (HCV) NS3/4A protease inhibitor, for the treatment of chronic hepatitis C virus infection. The phase Ia clinical trial is designed to assess the safety, tolerability, and pharmacokinetics in healthy volunteers. The study will be conducted in Europe.

The preclinical research conducted on the clinical candidate demonstrated favorable characteristics in potency, cross-resistance profiles and pharmacokinetic properties, supporting the exploration of oral dosing in the clinical trials.

This milestone triggers a payment of EUR 2.5 million to Medivir.

“As there is a great need of new and effective treatment for chronic hepatitis C, we are extremely pleased that this project with joint resources and efforts now enters clinical trials ” says Medivir’s CEO Lars Adlersson.

About Hepatitis C
Hepatitis C is a liver disease which is caused by infection with the hepatitis C virus (HCV). According to the WHO, 3% of the global population is infected with HCV, which means 200 million individuals. In the USA, 1.8% of the population is infected, that is 3.9 million people. In more than 60% of these cases, the HCV infection leads to chronic liver disease, cirrhosis and liver tumors. It is the most common reason for liver transplant. The HCV market is currently dominated by interferon-based treatments.

FOR FURTHER INFORMATION PLEASE CONTACT:
Rein Piir, CFO and VP Investor Relations Office: +46 8 546 831 23 or mobile: +46 708 537 292

About Us

Medivir is an emerging and profitable research‐based pharmaceutical company with an established marketing and sales organisation in the Nordic region with a broad portfolio of prescription pharmaceuticals.Medivir receives royalties from Johnson & Johnson on the global sales of the hepatitis C pharmaceutical, Olysio®. In addition, revenues for sales of Olysio in the Nordic region are generated through the company’s own sales and marketing organisation. Medivir’s research and development portfolio of pharmaceuticals is based on the company’s expertise within protease inhibitor design and nucleoside/nucleotide science. The company’s research and development focus is within infectious diseases and oncology and the on-going clinical projects in osteoarthritis and neuropathic pain. Medivir is listed on the Nasdaq Stockholm Mid Cap List.

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