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Genes, infection and autoimmune reaction behind narcolepsy

One of the world’s most prominent sleep and narcolepsy researchers is coming to Sweden to lecture at Karolinska Institutet. Professor Emmanuel Mignot is credited with the discovery that narcolepsy in dogs is attributable to a mutation in a sleep-regulating gene.
Karolinska Institutet invites you to a lecture titled “Gene-infection interplay in narcolepsy: an autoimmune disorder affecting hypocretin/orexin...

New gene variant may explain psychotic features in bipolar disorder

Researchers at Karolinska Institutet in Sweden have found an explanation for why the level of kynurenic acid (KYNA) is higher in the brains of people with schizophrenia or bipolar disease with psychosis. The study, which is published in the scientific periodical Molecular Psychiatry, identifies a gene variant associated with an increased production of KYNA. The discovery contributes to the further understanding of...

Cortisone can increase risk of acute pancreatitis

A new study from Karolinska Institutet in Sweden shows that cortisone – a hormone used in certain medicines – increases the risk of acute pancreatitis. The results are published in the scientific journal JAMA Internal Medicine. According to the researchers, they suggest that patients treated with cortisone in some forms should be informed of the risks and advised to refrain from alcohol and smoking.

Epigenetic changes can explain rheumatism

A new study by researchers at Karolinska Institutet in Sweden and Johns Hopkins University School of Medicine in the US shows that so-called epigenetic changes in the DNA are involved in causing rheumatoid arthritis, and that these changes can be genetically predetermined. The paper, which is published in the scientific periodical Nature Biotechnology, sheds light on how risk genes can be expressed in disease and...

Mind, Body and Cancer

Medical Doctor shares research on the benefits of meditation, yoga and Qigong
When it comes to cancer, there are obvious mind-body links. Stress, pessimism and other emotional factors have been proven to play a role, increasing the risk of cancer, metastasis and early mortality. This is a double-whammy for cancer patients, who must overcome anxiety from the moment they are diagnosed. In particular, stress has...

Atherosclerotic plaques formed during a late and limited time period in life

In a new study performed in humans, researchers from Sweden’s Karolinska Institutet have determined the age of atherosclerotic plaques by taking advantage of Carbon-14 (14C) residues in the atmosphere, prevailing after the extensive atomic bomb tests in the 50ties and 60ties. The findings, published in the scientific online journal PLoS ONE, suggest that in most people plaque formation occurs during a relatively...

Inflammation behind heart valve disease

Research from Karolinska Institutet in Sweden shows, that a specific inflammatory factor may be important in the development of the heart valve disease aortic stenosis. The results suggest that anti-inflammatory medication could be a possible new treatment.
 Aortic stenosis is the most common heart valve disease, which is caused by calcium deposits and a narrowing of the aortic valve. This is typically seen in...

Orexo and Boehringer Ingelheim report progress in their pain and inflammatory di...

Uppsala/Sweden and Ingelheim/Germany, December 16, 2010 - Orexo AB (STO: ORX) and Boehringer Ingelheim announced today that Boehringer Ingelheim has selected a development candidate resulting from the worldwide exclusive research, development and commercialisation agreement which Boehringer Ingelheim had signed in November 2005 with Biolipox, a Swedish research-based pharmaceutical company acquired by Orexo in ...