Strong growth in 2005 first half adjusted EPS : up 26.1% at €2.22 Increase in full year adjusted EPS guidance Positive phase IIb/III results for 6 products

Paris, August 31, 2005 Strong growth in 2005 first half adjusted EPS : up 26.1% at €2.22 Increase in full year adjusted EPS guidance Positive phase IIb/III results for 6 products The 2005 first-half consolidated income statement is presented in Appendix 4. Consolidated net income for the period came to €1,087 million. This figure includes a total of €1,881 million relating to the effects of the application of purchase accounting to the Aventis acquisition and to restructuring costs. As the acquisition of Aventis took place on August 20, 2004, the structure of the Group is not directly comparable year on year. In order to give a better representation of our underlying economic performance, we have decided to publish and explain adjusted consolidated income statements1 for the first half of 2005 and the second quarter of 2005, and to compare them with adjusted pro forma income statements1 for the first half of 2004 and the second quarter of 2004 respectively. Adjusted net income for the first half of 2005 was €2,968 million, compared with €2,336 million for the first half of 2004. All financial figures given in this press release are derived from accounting data prepared in accordance with international financial reporting standards (IFRS). SECOND QUARTER · Net sales: €6,687 million, up 6.5% (10.1% on a comparable basis) · Increase of 24.4% in “adjusted operating income – current” · Adjusted net income up 26.0% at €1,553 million · Adjusted earnings per share up 24.7% at €1.16 (vs. €0.93 for the second quarter of 2004). FIRST HALF · Net sales: €13,104 million, up 7.4% (11.0% on a comparable basis) · Increase of 26.1% in “adjusted operating income – current” · Adjusted net income up 27.1% at €2,968 million · Adjusted earnings per share up 26.1% at €2.22 (vs. €1.76 for the first half of 2004) EPS GUIDANCE Increase in 2005 full-year adjusted EPS guidance to at least 20%2 growth barring major adverse events. RESEARCH AND DEVELOPMENT Positive results for 6 products in late stage trials (2 Phase III results and 4 Phase IIb results). 1Refer to the Appendices for definitions of financial indicators 2 Based on an exchange rate of €1:$1.25. Sensitivity to the euro/dollar exchange rate is estimated at 0.5% of growth for a 1-cent movement in the exchange rate. Adjusted consolidated income statement (unaudited) The adjusted consolidated income statement (unaudited) is presented in Appendix 2. Please refer to Appendix 1 for a definition of “Proforma income statement” and “Adjusted net income”, and to Appendix 3 for reconciliations of the consolidated income statement to the adjusted consolidated income statement. Second quarter of 2005 (compared to 2004 second-quarter adjusted pro forma) Net sales generated by sanofi-aventis in the second quarter of 2005 came to €6,687 million, a rise of 10.1% on a comparable basis. Exchange rate movements had a negative effect of 2.8 points, and changes in Group structure a negative effect of 0.8 of a point. After taking account of these effects, net sales rose by 6.5% on a reported basis. Gross profit was €5,271 million, 9.6% up on the second quarter of 2004. The improvement in the gross margin ratio was more pronounced than in the first quarter; it rose by 2.2 points (against 1 point in the first quarter) to 78.8%, compared with 76.6% for the second quarter of 2004. Research and development expenses were 1.0% lower than in the second quarter of 2004 at €979 million, representing 14.6% of net sales. Selling and general expenses were €2,029 million. This was a slight increase (of 1.2%) on the 2004 second-quarter figure, and represented 30.3% of net sales (vs. 31.9% in the second quarter of 2004). Promotional expenses grew at a faster rate in the second quarter than in the first, while the reduction in general expenses was more marked in the second quarter than in the first. “Operating income – current” was 24.4% higher at €2,256 million, representing 33.7% of net sales, an improvement of 4.8 points relative to the 2004 second-quarter ratio of 28.9%. Operating income was up 22.1% at €2,229 million. Net financial expense was €99 million (vs. €183 million for the second quarter of 2004), slightly down on the 2005 first-quarter figure. Income tax expense was €652 million, compared with €475 million for the second quarter of 2004, giving an effective tax rate of 30.6% (vs. 28.9% for the second quarter of 2004). The share of profits from associates for the second quarter of 2005 was €162 million, compared with €140 million for the second quarter of 2004. This line includes the Group’s share of after-tax profits from the territories managed by BMS under the Plavix® and Avapro® alliance (€103 million, vs. €87 million for the second quarter of 2004). Minority interests in net income amounted to €87 million, against €74 million for the second quarter of 2004. This line includes the share of pre-tax profits paid over to BMS from territories managed by sanofi-aventis (€69 million, vs. €60 million for the second quarter of 2004). Net income was 26.0% higher at €1,553 million, and represented 23.2% of net sales (vs. 19.6% for the second quarter of 2004). Earnings per share (EPS) was €1.16, 24.7% up on the 2004 second-quarter figure of €0.93, based on an average of 1,335,764,969 shares for the second quarter of 2005 and 1,325,855,679 shares for the second quarter of 2004. First half of 2005 (compared to 2004 first-half adjusted pro forma) Net sales generated by sanofi-aventis in the first half of 2005 amounted to €13,104 million, up 11.0% on a comparable basis. Exchange rate movements had a negative effect of 2.4 points, and changes in Group structure a negative effect of 1.1 points. After allowing for these impacts, reported-basis growth was 7.4%. Gross profit was up 9.8% on the first half of 2004 at €10,234 million. The gross margin ratio was 78.1%, against 76.5% for the first half of 2004. This improvement was due to the combined effect of sales growth, productivity gains and purchasing efficiencies. Research and development expenses were virtually unchanged relative to the first half of 2004 at €1,902 million, or 14.5% of net sales. This level of expenditure reflects the impact of restructuring initiated by Aventis prior to the acquisition and the discontinuation of some R&D collaborations. Selling and general expenses were 1% up on the 2004 first-half figure at €3,949 million, equivalent to 30.1% of net sales. This trend reflects strong growth in promotional expenses, coupled with a substantial reduction in general expenses. Other current operating income came to €133 million, against €89 million for the first half of 2004. This increase mainly reflects the effect of alliances, in particular the share of profits to which sanofi-aventis is entitled on non-consolidated sales of Actonel®. “Operating income – current” was 26.1% higher at €4,399 million, representing 33.6% of net sales, a 5-point improvement relative to the first half of 2004. Net other operating income came to €7 million, compared with €194 million for the first half of 2004. In 2004, this line included gains on disposals of €348 million (mainly from disposals made by Aventis) and bid defense costs of €161 million. Operating income was 22.1% higher at €4,376 million, and represented 33.4% of net sales compared with 29.4% for the first half of 2004. Net financial expense was €205 million, against €393 million for the first half of 2004. This decrease reflects a lower cost of debt capital, a reduction in debt due to cash flow generated by the Group, and a favorable effect from the remeasurement of financial instruments. Income tax expense was €1,302 million, compared with €947 million for the first half of 2004, giving an effective tax rate of 31.2% for the first half of 2005 (vs. 29.7% for the first half of 2004). The share of profit from associates came to €269 million, compared with €233 million for the first half of 2004. This line includes the Group’s share of after-tax profits from the territories managed by BMS under the Plavix® and Avapro® alliance (€183 million, vs. €158 million for the first half of 2004). Minority interests in net income amounted to €170 million, against €141 million for the second half of 2004. This line includes the share of pre-tax profits paid over to BMS from territories managed by sanofi-aventis (€138 million, vs. €115 million for the first half of 2004). Net income was up 27.1% at €2,968 million, equivalent to 22.6% of net sales (vs. 19.2% for the first half of 2004). Earnings per share (EPS) was €2.22, 26.1% higher than the 2004 first-half figure of €1.76, based on an average of 1,335,141,552 shares for the first half of 2005 (vs. 1,325,459,971 for the first half of 2004). Consolidated cash flow and net debt Net cash provided by operating activities in the first half of 2005 totaled €3,396 million. Acquisitions of property, plant and equipment and intangibles amounted to €507 million. After paying out a dividend of €1,613 million, free cash flow was €1,422 million, enabling consolidated net debt (defined as short-term debt plus long-term debt, net of cash and cash equivalents) to be reduced from €14.2 billion at end December 2004 to €12.8 billion at end June 2005. 2005 guidance The excellent first-half performance means that, barring major adverse events, sanofi-aventis expects 2005 full-year adjusted EPS growth at least 20% (based on an exchange rate of €1: $1.25, with sensitivity to the euro/dollar exchange rate estimated at 0.5% of growth for a 1-cent movement in the exchange rate). This takes account of substantial expenditure in preparation for the launch of Rimonabant, the launch costs of Ambien CR, and increased spending on clinical trials, all of which are expected to be incurred in the second half of the year. Sanofi-aventis expects 2005 full-year comparable-basis growth in net sales to be ahead of the world pharmaceutical market growth rate. Research and development update Sanofi-aventis announces the results of phase IIb/III trials on six late stage compounds, representing the first wave of clinical results expected in 2005. Results are available for three Central Nervous System (CNS) compounds, two compounds in Oncology and one in Internal Medicine. The presentation of this results is available on the Group Website under the heading “Investors” : www.sanofi-aventis.com. SR 58611 in recurrent major depression: The EFC5374 Phase III study of 280 patients in Europe met its primary objective of demonstrating the improvement of depressive symptoms over placebo after treatment of 6 weeks. In a more severe population of depressive patients the results were even more impressive. The EFC 5379 Phase III study in North America was non conclusive (non significant difference between reference compound and placebo) for efficacy. The combined safety analysis of the two studies demonstrated a good overall safety profile for SR 58611. Eplivanserin in sleep maintenance insomnia: The Phase IIb study of 350 patients met its primary objective to improve sleep maintenance. In comparison to placebo, the drug reduces WASO (Wake After Sleep Onset) and the number of awakenings. It also increases TST (Total Sleep Time) and improves refreshing quality of sleep. All these results were statistically significant while no next day residual effect or rebound insomnia was observed after treatment discontinuation. Eplivanserin demonstrated safety comparable to placebo. SSR 591813 in smoking cessation: The primary objective of the DRI5154 Phase IIb study of 527 patients was to compare the efficacy of three fixed doses of SSR 591813 versus placebo on abstinence in cigarette smokers. In treatment completers, all doses of SSR 591813 met its primary efficacy criteria of prolonged abstinence during the last four weeks of treatment. The overall safety profile of the product was acceptable. Xaliproden in severe peripheral sensory neuropathy (PSN) induced by chemotherapy (oxaliplatin): The Xenox Phase III study of 649 metastatic colorectal cancer patients treated with FOLFOX4 regimen met its primary efficacy criterion of decrease in the risk of occurrence of severe PSN (peripheral sensory neuropathy), and response rate of chemotherapy was not negatively impacted with the addition of Xaliproden. The relative risk of cumulative Grade 3 PSN was reduced by 39%. Alvocidib in refractory Chronic Lymphocytic Leukemia (CLL): In a study of 23 patients with CLL who failed fludarabine treatment, Alvocidib activity was demonstrated to be comparable to that of second-line Campath or fludarabine, with an acceptable safety profile. SR 121463 in cirrhotic ascites: The HypoCAT Phase IIb study in 110 hyponatremic patients with cirrhotic ascites met its primary endpoint to change serum sodium levels on day 5 compared to baseline. The NormoCAT Phase IIb study in 148 normonatremic patients with cirrhotic ascites met its primary endpoint to change in body weight gain at the end of treatment compared to baseline. In both studies SR 121463 induced an increase in 24-hour urine volume as compared to placebo. Pooled safety data of HypoCAT and NormoCAT studies confirm the good safety profile observed in Phase IIa (increased thirst only). Trials in VTE prevention in Atrial Fibrillation patients: Sanofi-aventis is evaluating Idraparinux and Plavix in the prevention of Veinous Thromboembolism (VTE) in patients with atrial fibrillation by means of the Amadeus and Active programs begun in 2003. In Amadeus, idraparinux is compared to vitamin K antagonist. In Active W, the activity of clopidogrel 75 + Asa is compared to vitamin K antagonist. The steering committees of both these trials have observed a substantially lower incidence of events than initially planned. As a result, sanofi-aventis has been asked to increase the number of patients in these trials. Sanofi-aventis has decided in agreement with the steering committee and the DSMB to make no further recruitments in the Amadeus program. The principal reason was the very large number of patients required in order to show statistical significance. Results on already recruited patients are expected to be available in 2006. The Van Gogh program in the treatment of VTE and Pulmonary Embolism is progressing as planned. The number of patients to be recruited in the Active W (clopidogrel) program is being increased. Development programs stopped since March 1, 2005 Two programs in phase IIb, three in Phase I and three in pre clinical stages were stopped due to various reasons. The phase IIb molecules involved were Pranalcasan (HMR 3480) and Osanetant (SR 142801). New products in the R&D portfolio Eight products are entering the development pipeline, including Alvocidib which is moving directly into phase III trials in Chronic Lymphocytic Leukemia. Recent events July 25, 2005Sanofi pasteur begins shipping AdacelTM vaccine in the United States July 27, 2005Launch of Allegra®-D 24 hours in the United States August 5, 2005Withdrawal of Plavix® litigation in the United Kingdom August 8, 2005Announcement of disposal of sanofi-aventis’ interests in Wacker-Chemie GmbH August 16, 2005Approval of Actonel with Calcium® in the United States August 18, 2005Publication in the Journal of Clinical Oncology of a phase III trial results which demonstrate that in women with advanced breast cancer Taxotere® significantly improves survival compared with paclitaxel 2005 Financial Diary November 8, 2005 2005 third-quarter sales and results APPENDICES: List of appendices: Appendix 1: Explanatory notes Appendix 2: 2005 second-quarter and first-half adjusted consolidated financial statements (unaudited) Appendix 3: 2005 second-quarter and first half reconciliations of consolidated income statements to adjusted consolidated income statements (unaudited) Appendix 4: 2005 first-half consolidated income statement Appendix 5: Simplified consolidated balance sheets and simplified consolidated statement of cash flows Appendix 1: Explanatory notes Comparable net sales: When we refer to the change in our sales on a “comparable” basis, we mean that we exclude the impact of exchange rate movements and changes in Group structure (acquisitions and divestments of interests in entities and rights to products, and changes in consolidation method for consolidated entities). For any two periods, we exclude the impact of exchange rates by recalculating sales for the earlier period on the basis of exchange rates used in the later period. We exclude the impact of acquisitions by including sales for a portion of the prior period equal to the portion of the current period during which we owned the entity or product rights based on sales information we receive from the party from whom we make the acquisition. Similarly, we exclude sales in the relevant portion of the prior period when we have sold an entity or rights to a product. For a change in consolidation method, the prior period is recalculated on the basis of the method used for the current period. Reconciliation of 2004 pro forma reported net sales to 2004 pro forma comparable net sales € millionH1 2004 Pro forma reported net sales 12,196 Impact of changes in Group structure(123) Impact of exchange rates (266) Pro forma comparable net sales11,807 € millionQ2 2004 Pro forma reported net sales 6,277 Impact of changes in Group structure(50) Impact of exchange rates (156) Pro forma comparable net sales6,071 Adjusted net income: We define “adjusted net income” as accounting net income (determined under IFRS) adjusted to exclude (i) the material impacts of purchase accounting for the Aventis acquisition and (ii) acquisition-related integration and restructuring costs. Sanofi-aventis believes that eliminating these impacts from net income gives investors a better understanding of the underlying economic performance of the combined Group. The material impacts of the application of purchase accounting to the acquisition are as follows: - charges arising from the remeasurement of Aventis inventories at fair value, net of tax; - amortization/impairment expense generated by the remeasurement of Aventis intangible assets, net of tax; - any impairment charged against the goodwill arising on the acquisition. Sanofi-aventis also excludes acquisition-related integration and restructuring costs from adjusted net income. 2004 second-quarter and first-half adjusted pro forma income statements are presented for comparability purposes as though the offer for Aventis, and the transactions described below, had occurred on January 1, 2004. The basis of preparation of the pro forma income statements is as follows: - no impact on the income statement of the remeasurement of inventories; - elimination of the income statement contribution of Arixtra, Fraxiparine and Campto (no impact of gains on disposal in the first half); - elimination of Aventis Behring, divested at the start of 2004. € million H1 2005 consolidated H1 2005 adjusted consolidated (unaudited)H1 2004 adjusted pro forma (unaudited)H1 2004** Net sales 13,10413,10412,1964,394 Net income1,0872,9682,3361,115 Basic EPS (in euros)0.812.221.761.63 * The first-half consolidated financial statements have been subject to a limited review by the statutory auditors in accordance with French auditing standards. **Sanofi-Synthélabo income statement for the first half of 2004 € million Q2 2005 consolidated (unaudited)Q2 2005 adjusted consolidated (unaudited)Q2 2004 adjusted pro forma (unaudited) Net sales 6,6876,6876,277 Net income5561,5531,233 Basic EPS (in euros)0.411.160.93 Appendix 2: 2005 second-quarter and first-half adjusted consolidated financial statements (unaudited) The adjusted consolidated income statements are derived from the consolidated income statements as presented in Appendix 3 Sanofi-aventis 2005 second-quarter adjusted consolidated income statement € million Q2 2005 Adjusted consolidated income statement (unaudited) as % of net sales Q2 2004 Adjusted pro forma income statement (unaudited) as % of net sales % change Net sales6,687100%6,277100%+6.5% Other revenues3054.6%2864.6%+6.6% Cost of sales(1,721)(25.8%)(1,754)(28.0%)-1.9% Gross profit5,27178.8%4,80976.6%+9.6% Research & development expenses(979)(14.6%)(989)(15.8%)-1.0% Selling & general expenses(2,029)(30.3%)(2,005)(31.9%)+1.2% Other current operating income56-48-+16.6% Other current operating expenses(37)-(21)-- Amortization of intangibles(26)-(28)-- Operating income – current2,25633.7%1,81428.9%+24.4% Restructuring costs(14)-(46)--69.6% Impairment of PP&E and intangibles(3)---- Other operating income and expenses(10)-57-- Operating income2,22933.3%1,82529.1%+22.1% Financial expenses(143)-(264)--45.8% Financial income44-81--45.7% Income before tax and associates2,13031.9%1,64226.2%+29.7% Income tax expense(652)(9.8%)(475)(7.6%)+37.3% Effective tax rate30.6%-28.9%-- Share of profit/loss of associates 162-140-+15.7% Net income before minority interests1,64024.5%1,30720.8%+25.5% Minority interests(87)-(74)-+17.6% Net income1,55323.2%1,23319.6%+26.0% Average number of shares outstanding1,335,764,969-1,325,855,679-- Earnings per share (in euros)1.16 0.93-+24.7% Sanofi-aventis 2005 first-half adjusted consolidated income statement € million H1 2005 Adjusted consolidated income statement (unaudited) as % of net sales H1 2004 Adjusted pro forma income statement (unaudited) as % of net sales % change Net sales13,104100%12,196100%+7.4% Other revenues5484.2%5074.2%+8.1% Cost of sales(3,418)(26.1%)(3,379)(27.7%)+1.2% Gross profit10,23478.1%9,32476.5%+9.8% Research & development expenses(1,902)(14.5%)(1,909)(15.7%)-0.4% Selling & general expenses(3,949)(30.1%)(3,911)(32.1%)+1.0% Other current operating income133-89-+49.4% Other current operating expenses(64)-(48)-- Amortization of intangibles(53)-(56)--5.4% Operating income – current4,39933.6%3,48928.6%+26.1% Restructuring costs(27)-(99)--72.7% Impairment of PP&E and intangibles(3)---- Other operating income and expenses7-194-- Operating income4,37633.4%3,58429.4%+22.1% Financial expenses(305)-(492)--38.0% Financial income100-99-+1.0% Income before tax and associates4,17131.8%3,19126.2%+30.7% Income tax expense(1,302)(10.0%)(947)(7.7%)+37.5% Effective tax rate31.2%-29.7%-- Share of profit/loss of associates 269-233-+15.5% Net income before minority interests3,13823.9%2,47720.3%+26.7% Minority interests(170)-(141)-+20.6% Net income2,96822.6%2,33619.2%+27.1% Average number of shares outstanding1,335,141,552 1,325,459,971 - Earnings per share (in euros)2.22 1.76 +26.1% Appendix 3: 2005 second-quarter and first half reconciliations of consolidated income statements to adjusted consolidated income statements (unaudited) Second quarter of 2005: The adjustments to the income statement reflect the elimination of material impacts of the application of purchase accounting to the Aventis acquisition (€768 million net of deferred taxes, with no cash impact for the Group) and restructuring charges (€229 million net of tax), i.e. a total impact of €997 million. 2005 second-quarter reconciliation of consolidated income statement to adjusted consolidated income statement (unaudited) € million Q2 2005 consolidated (unaudited) AdjustmentsQ2 2005 adjusted consolidated (unaudited) Net sales6,687 6,687 Other revenues305 305 Cost of sales(1,861)140 (a)(1,721) Gross profit5,1311405,271 Research & development expenses(979) (979) Selling & general expenses(2,029) (2,029) Other current operating income56 56 Other current operating expenses(37) (37) Amortization of intangibles(982)956 (b)(26) Operating income – current1,1601,0962,256 Restructuring costs(367)353 (c)(14) Impairment of PP&E and intangibles(106)103 (d)(3) Other operating income and expenses(10) (10) Operating income6771,5522,229 Financial expenses(143) (143) Financial income44 44 Income before tax and associates5781,5522,130 Income tax expense(78)(574) (e)(652) Effective tax rate13.5% 30.6% Share of profit/loss of associates 13626 (f)162 Net income before minority interests6361,0041,640 Minority interests(80)(7) (g)(87) Net income5569971,553 Average number of shares outstanding1,335,764,969 1,335,764,969 Earnings per share (in euros)0.42 1.16 The material impacts of the application of purchase accounting to the Aventis acquisition and of restructuring charges on the 2005 second-quarter consolidated income statement are as follows: · (a) A charge arising from the workdown of acquired inventories remeasured at fair value. · (b) An amortization charge of €956 million against intangible assets. This adjustment has no cash impact on the Group. · (c) A pre-tax restructuring charge of €353 million. · (d) Impairment losses of €103 million. · (e) The tax impact primarily comprises : 1) Deferred taxes of €449 million generated by the amortization charge of €956 million taken against intangible assets, by impairment of property, plant and equipment and intangibles of €103 million, and by the €140 million charge arising from the workdown of acquired inventories remeasured at fair value. This adjustment has no cash impact on the Group. 2) An income tax effect of €124 million on the €353 million of restructuring charges. · (f) In “Share of profit/loss from associates”, a charge of €26 million corresponding to the amortization of intangibles (net of tax) and the workdown of acquired inventories. This adjustment has no cash impact on the Group. · (g) In “Minority interests”, an impact of €7 million representing the share attributable to minority shareholders of charges for the amortization and impairment of intangibles. This adjustment has no cash impact on the Group. First half of 2005: The adjustments to the income statement reflect the elimination of material impacts of the application of purchase accounting to the Aventis acquisition (€1,484 million net of deferred taxes, with no cash impact for the Group) and restructuring charges (€397 million net of tax), i.e. a total impact of €1,881 million. 2005 first-half reconciliation of consolidated income statement to adjusted consolidated income statement (unaudited) € million H1 2005 consolidated* AdjustmentsH1 2005 adjusted consolidated (unaudited) Net sales13,104-13,104 Other revenues548-548 Cost of sales(3,690)272 (a)(3,418) Gross profit9,96227210,234 Research & development expenses(1,902) (1,902) Selling & general expenses(3,949) (3,949) Other current operating income133 133 Other current operating expenses(64) (64) Amortization of intangibles(1,970)1,917 (b)(53) Operating income – current2,2102,1894,399 Restructuring costs(638)611 (c)(27) Impairment of PP&E and intangibles(106)103 (d)(3) Other operating income and expenses7-7 Operating income1,4732,9034,376 Financial expenses(305)-(305) Financial income100-100 Income before tax and associates1,2682,9034,171 Income tax expense(232)(1,070) (e)(1,302) Share of profit/loss of associates 20861 (f)269 Net income before minority interests1,2441,8943,138 Minority interests(157)(13) (g)(170) Net income1,0871,8812,968 Average number of shares outstanding1,335,141,552 1,335,141,552 Earnings per share (in euros)0.81 2.22 * The first-half consolidated financial statements have been subject to a limited review by the statutory auditors in accordance with French auditing standards. The material impacts of the application of purchase accounting to the Aventis acquisition and of restructuring charges on the 2005 first-half consolidated income statement are as follows: · (a) A charge arising from the workdown of acquired inventories remeasured at fair value. · (b) An amortization charge of €1,917 million against intangible assets. This adjustment has no cash impact on the Group. · (c) A pre-tax restructuring charge of €611 million. · (d) Impairment losses of €103 million. · (e) The tax impact primarily comprises : 1) Deferred taxes of €855 million generated by the amortization charge of €1,917 million taken against intangible assets, by impairment of property, plant and equipment and intangibles of €103 million, and by the €272 million charge arising from the workdown of acquired inventories remeasured at fair value. This adjustment has no cash impact on the Group. 2) An income tax effect of €214 million on the €611 million of restructuring charges. · (f) In “Share of profit/loss from associates”, a charge of €61 million corresponding to the amortization of intangibles (net of tax) and the workdown of acquired inventories. This adjustment has no cash impact on the Group. · (g) In “Minority interests”, an impact of €13 million representing the share attributable to minority shareholders of charges for the amortization and impairment of intangibles. This adjustment has no cash impact on the Group. Appendix 4: 2005 first-half consolidated income statement The first-half consolidated financial statements have been subject to a limited review by the statutory auditors in accordance with French auditing standards. Sanofi-aventis 2005 first-half consolidated income statement € million H1 2005 Consolidated income statement H1 2004 Consolidated income statement* Net sales13,1044,394 Other revenues548324 Cost of sales(3,690)(1,051) Gross profit9,9623,667 Research & development expenses(1,902)(707) Selling & general expenses(3,949)(1,393) Other current operating income13337 Other current operating expenses(64)(6) Amortization of intangibles(1,970)(67) Operating income – current2,2101,531 Restructuring costs(638)- Impairment of PP&E and intangibles(106)- Other operating income and expenses79 Operating income1,4731,540 Financial expenses(305)(33) Financial income10042 Income before tax and associates1,2681,549 Income tax expense(232)(500) Effective tax rate18.3%32.3% Share of profit/loss of associates 208183 Net income before minority interests1,2441,232 Minority interests(157)(117) Net income1,0871,115 Average number of shares outstanding1,335,141,552683,056,982 Earnings per share (in euros)0.811.63 *Sanofi-Synthélabo income statement for the first half of 2004 Appendix 5: Sanofi-aventis simplified consolidated balance sheets and simplified consolidated statement of cash flows The first-half consolidated financial statements have been subject to a limited review by the statutory auditors in accordance with French auditing standards. Simplified consolidated statement of cash flows € millionH1 2005 Adjusted consolidated net income2,968 Depreciation, amortization & impairment of property, plant & equipment and intangibles 498 Impact of restructuring costs, net of tax (266) Other items114 Operating cash flow before changes in working capital3,314 Changes in working capital82 Net cash provided by operating activities 3,396 Acquisitions of property, plant & equipment and intangibles (507) Proceeds from disposals of property, plant & equipment and intangibles 116 Other items(12) Net cash used in investing activities (403) Dividends(1,613) Other items42 Change in net debt1,422 Sanofi-aventis simplified consolidated balance sheets € million ASSETS30/06/0531/12/04*LIABILITIES & EQUITY30/06/0531/12/04* Property, plant and equipment 5,9775,892Shareholders’ equity44,19241,061 Intangible assets (incl. goodwill)63,15361,567Minority interests422462 Non-current financial assets, investments in associates and deferred taxes 7,0585,985Total equity44,61441,523 Long-term debt7,1278,654 Non-current assets76,18873,444Provisions and other non-current liabilities 7,6796,929 Deferred taxes13,60613,123 Inventories, accounts receivable & other current assets10,3989,475Non-current liabilities 28,41228,706 Financial assets – current463648Accounts payable & other current liabilities 8,3707,790 Cash and equivalents, short-term investments & deposits 2,2641,840Short-term debt7,9177,388 Current assets13,12511,963Current liabilities16,28715,178 TOTAL ASSETS89,31385,407TOTAL LIABILITIES & EQUITY89,31385,407 *As allowed under IFRS 3, sanofi-aventis has reviewed some aspects of the Aventis purchase price allocation within the permitted 12-month period REMINDER – INFORMATION BRIEFINGS Paris: August 31, 2005 - 09.00 CET: Presentation of 2005 first-half results to financial analysts, investors and journalists at the Hotel George V (31 avenue George V, 75008 Paris). The presentation will be in French, with simultaneous translation into English. You can follow the live webcast on www.sanofi-aventis.com; you can also listen to the presentation, but only by dialing one of the conference call numbers listed below. - 15.00 CET Conference call, with video webcast of the 2005 first-half results presentation available in English on www.sanofi-aventis.com. We can only accept questions by telephone: Conference call numbers for both events: France: + 33 (0)1 55 17 41 48 UK : + 44 (0) 207 784 10 18 USA : + 1 718 354 11 71 Replay numbers: France: + 33 (0)1 71 23 02 48 (available until September 9, 2005) UK : + 44 (0) 207 784 10 24 USA : + 1 718 354 11 12 Meeting code: 09.00: 8249805# Meeting code: 15.00: 9296499# Recordings of both presentations will be available on www.sanofi-aventis.com New York: September 29, 2005 Presentation of 2005 first-half results at the St. Regis Hotel, New York (2 East 55th St., corner of 5th Avenue) at 13.00 EST. Forward-Looking Statements This press release contains forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995. Forward-looking statements are statements that are not historical facts. These statements include financial projections and estimates and their underlying assumptions, statements regarding plans, objectives and expectations with respect to future operations, products and services, and statements regarding future performance. Forward-looking statements are generally identified by the words “expect,” “anticipates,” “believes,” “intends,” “estimates,” “plans” and similar expressions. Although sanofi-aventis’ management believes that the expectations reflected in such forward-looking statements are reasonable, investors are cautioned that forward-looking information and statements are subject to various risks and uncertainties, many of which are difficult to predict and generally beyond the control of sanofi-aventis, that could cause actual results and developments to differ materially from those expressed in, or implied or projected by, the forward-looking information and statements. These risks and uncertainties include those discussed or identified in the public filings with the SEC and the AMF made by sanofi-aventis, including those listed under “Risk Factors” and “Cautionary Statement Regarding Forward-Looking Statements” in sanofi-aventis’ annual report on Form 20-F for the year ended December 31, 2004. Other than as required by applicable law, sanofi-aventis does not undertake any obligation to update or revise any forward-looking information or statements. The sanofi-aventis Group conducts its business in the United States through its subsidiaries Sanofi-Synthélabo Inc., Aventis Pharmaceuticals Inc. and Sanofi Pasteur Inc. Investor Relations Department Europe Tel: + 33 1 53 77 45 45 US Tel: +1 212 551 4018 e-mail: IR@sanofi-aventis.com ------------------------------------------------------------ Informasjonen er sendt gjennom Waymaker http://www.waymaker.no

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Et stort farmasøytisk selskap som setter fokus på helse over hele verden. Med en nettoomsetning i 2004 på 26 750 millioner euro, og mer enn 100 000 ansatte i rundt 100 land er Sanofi-aventis er et av verdens ledende legemiddel selskap og er blant topp 6 i Norge. Det globale hovedkontoret er i Paris, Frankrike. Det norske hovedkontoret befinner seg på Lysaker. 7 viktige behandlingsområder Sanofi-aventis fokuserer sine aktiviteter på 7 viktige behandlingsområder: Hjerte-karsykdommer (f. eks. Hypertensjon)Thrombose (Blodpropp)Onkologi (Kreft)Sykdommer i sentralnervesystemet (f.eks. MS) DiabetesOsteoporose (Benskjørhet) Gode legemidler for millioner av pasienter Sanofi-aventis’ portefølje av markedsførte produkter inkluderer flere legemidler som er verdensledere i sine respektive klasser, innen områdene blodpropp, hjerte-karsykdommer, søvnforstyrrelser, epilepsi, diabetes og kreft. Svært produktiv og nyskapende forskning og utvikling Grunnlaget for sanofi-aventis' verdensomspennende fremgang er en svært produktiv og nyskapende forsknings- og produktutviklingsorganisasjon med rundt 11 000 forskere som jobber i mer enn 20 forskningssentere på tre kontinenter. Her legger vi vekt på å forske frem nyskapende terapeutiske behandlinger. For øyeblikket er rundt tretti forsknings- og produktutviklingsprosjekter kommet meget langt i utviklingen. Se forøvrig hjemmesiden til Legemiddelindustriforeningen. For mer informasjon om sanofi-aventis rundt om i verden kan du besøke www.sanofi-aventis.com.

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