Director/PDMR Shareholding

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16 December 2016 13:00

Transaction by a Person Discharging Managerial Responsibilities

Disclosure under Articles 19(3) and 19(6) of the EU Market Abuse Regulation

On 16 December 2016, Pascal Soriot, a Director of the Company, notified us that, on 16 December 2016, he ceased to be beneficially interested in 59,951 AstraZeneca PLC Ordinary Shares of $0.25 each as a result of a gift of those shares to family members for nil consideration.

The attached notification, made in accordance with the requirements of the EU Market Abuse Regulation, gives further detail.

Notification and public disclosure of transactions by persons discharging managerial responsibilities and persons closely associated with them

1 Details of   the person discharging managerial responsibilities / person closely   associated
a) Name Pascal Soriot
2 Reason for   the notification
a) Position/status Chief Executive Officer
b) Initial notification /Amendment Initial notification
3 Details of   the issuer, emission allowance market participant, auction platform,   auctioneer or auction monitor
a) Name AstraZeneca PLC
b) LEI Not applicable
4 Details of   the transaction(s): section to be repeated for (i) each type of instrument;   (ii) each type of transaction; (iii) each date; and (iv) each place where   transactions have been conducted
a) Description of the financial instrument, type of   instrumentIdentification code Ordinary Shares of US$0.25 each in AstraZeneca   PLCGB0009895292
b) Nature of the transaction Gift of shares to family members for nil   consideration
c) Price(s) and volume(s) Price(s) Volume(s)
0 59,951
d) Aggregated information- Aggregated volume- Price Not applicable - single transaction
e) Date of the transaction 16 December 2016
f) Place of the transaction London

About AstraZeneca

AstraZeneca is a global, science-led biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines, primarily for the treatment of diseases in three main therapy areas - Oncology, Cardiovascular & Metabolic Diseases and Respiratory. The Company also is selectively active in the areas of autoimmunity, neuroscience and infection. AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide. For more information, please visit www.astrazeneca.com and follow us on Twitter @AstraZeneca.

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Adrian Kemp

Company Secretary, AstraZeneca PLC

-ENDS-

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