Total Voting Rights

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01 September 2017 15:00 BST

Transparency Directive

Voting Rights and Capital

The following notification is made in accordance with the UK Financial Conduct Authority's Disclosure and Transparency Rule 5.6.1. As at 31 August 2017 the issued share capital of AstraZeneca PLC with voting rights is 1,265,897,109 ordinary shares of US$0.25. No shares are held in Treasury. Therefore, the total number of voting rights in AstraZeneca PLC is 1,265,897,109.

The above figure for the total number of voting rights may be used by shareholders as the denominator for the calculations by which they will determine if they are required to notify their interest in, or a change to their interest in, AstraZeneca PLC under the UK Financial Conduct Authority's Disclosure and Transparency Rules.

About AstraZeneca

AstraZeneca is a global, science-led biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines, primarily for the treatment of diseases in three therapy areas - Oncology, Cardiovascular & Metabolic Diseases and Respiratory. The Company also is selectively active in the areas of autoimmunity, neuroscience and infection. AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide.

For more information, please visit www.astrazeneca.com and follow us on Twitter @AstraZeneca.

Media Relations
Esra Erkal-Paler UK/Global +44 203 749 5638
Rob Skelding UK/Global +44 203 749 5821
Karen Birmingham UK/Global +44 203 749 5634
Matt Kent UK/Global +44 203 749 5906
Jacob Lund Sweden +46 8 553 260 20
Michele Meixell US +1 302 885 2677
Investor Relations
Thomas   Kudsk Larsen +44 203 749 5712
Craig   Marks Finance, Fixed Income, M&A +44 7881 615 764
Henry   Wheeler Oncology +44 203 749 5797
Mitchell   Chan Oncology +1 240 477 3771
Christer   Gruvris Diabetes; Autoimmunity, Neuroscience & Infection +44 203 749 5711
Nick   Stone Respiratory; Brilinta +44 203 749 5716
US   toll free +1 866 381 7277

Adrian Kemp

Company Secretary

AstraZeneca PLC

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