Ziccum achieves proof-of-concept in new antibody study

80% of human immunoglobulin antibodies, used to treat a wide range of diseases, are formulated as liquids, which can mean they are fragile, unstable and costly to transport. New results show that Ziccum AB’s spray drying instrument LaminarPace can produce a stable dry powder form of immunoglobulin antibodies—with confirmed activity. ‘This is an important milestone,’ says Ziccum CEO Göran Conradson.    

The tests, carried out in ISAB’s labs, dried three samples of liquid Immunoglobulin G (IgG) at room temperature, achieving high yields of powder. 25.5 mg of dry powder IgG was generated from a sample volume of 2 mL containing 30 mg of IgG, a yield of 85%. After the dry powder had been reconstituted back into water, the antibodies were confirmed active.

Ziccum AB CEO Göran Conradson: “This is a resounding proof of concept for LaminarPace. Being able to dry antibodies, hugely increases their stability and allows companies to keep them biologically active. It confirms our conviction that LaminarPace can help research, pharma and healthcare organizations everywhere reach new findings and markets.”

Ziccum AB, an ISAB subsidiary, has recently attracted capital funding of 2 MSEK. Ziccum expects to be listed independently in Q4 2018. Its flagship product, LaminarPace system, dries biologics, vaccines, drug substances and chemicals at room temperature—transforming often delicate, difficult-to-transport liquids, into stable, effective dry powders that require no refrigeration or cold storage.

Ziccum AB will publish the full technical report on the tests, including all data and images, on ziccum.com within the next two weeks.

For more information about Ziccum or Inhalation Sciences please contact:

Fredrik Sjövall, CEO 
Email: fredrik.sjovall@inhalation.se
Phone: +46 (0)70 64 508 75

About Inhalations Sciences Sweden AB (publ)

Inhalation Sciences Sweden AB (publ) develops and commercializes world-leading instruments for research into inhalation. The company’s patented lab instrument, PreciseInhale®, enables researchers to characterize, with high precision, how aerosols and small particles impact our lungs, and so our health, when we breathe them in.

About Ziccum AB

Ziccum AB develops and commercializes the patented spray-drying instrument LaminarPace®. LaminarPace is an innovative, CE-labelled instrument that dries small amounts of drug substances with very low losses. The vast majority of pharmaceutical projects prefer substances in dry powder form, as it increases their stability, durability and simplifies logistics and transportation. LaminarPace is also unique in its ability to handle temperature-sensitive materials such as proteins and peptides.

The information above was provided by Inhalation Sciences Sweden AB (publ) according to EU Market Abuse Regulations. The information was provided, through the above contact person, for publication on January 31, 2018.

About Us

Inhalation Sciences Sweden AB (publ.) develops and sells patented, highly innovative labtech equipment for inhalation research. Scientists using it can now know, with unprecedented accuracy, how particles behave in our lungs when we inhale them: whether new pollutants or life-saving drugs that power human development.


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