Natto: Statins Inhibit Vitamin K2 and Stimulate Hardening of the Arteries: New Review Paper

OSLO, NORWAY and METUCHEN, NJ – (May 19, 2015) A new paper published in Expert Review Clinical Pharmacology online ahead of print states that statins may act as “mitochondrial toxins” with negative effects on the heart and blood vessels not only via the depletion of coenzyme Q10 (CoQ10), but also by inhibing “the synthesis of vitamin K2, the cofactor for matrix Gla-protein activation, which in turn protects arteries from calcification.” 

Vitamin K2 plays a critical role in the activation of matrix Gla protein (MGP), which inhibits soft tissue and cardiovascular calcification. MGP is present in bone, blood vessel, lung, heart, and kidney soft tissues. MGP binds calcium and protects blood vessels from calcification, but only when in its active form, which requires adequate intakes of vitamin K2. Unfortunately, statins inhibit vitamin K2 synthesis in the body, thereby accelerating coronary artery calcification, an important marker of the progress of atherosclerosis, according to researchers.

“This new paper speaks directly to statins interrupting the mechanism of action by which vitamin K2 inhibits calcification,” said Hogne Vik, NattoPharma CEO. “Conversely, research clearly demonstrates that increasing dietary vitamin K2, specifically vitamin K2 as menaquinone-7, can improve vitamin K2 levels in the blood and tissues, thus promoting cardiovascular health.”

Supporting Vik’s statement, a new study, “Menaquinone-7 Supplementation Improves Arterial Stiffness in Healthy Postmenopausal Women,” published in the journal Thrombosis and Haemostasis, demonstrated the positive impact of MenaQ7® brand Vitamin K2 as MK-7 (menaquinone-7) on cardiovascular health through its improvement of arterial flexibility. This study is significant because it is an interventional study with a vitamin K2 dietary supplement, MenaQ7, confirming what previous population-based studies have shown: a positive correlation of vitamin K2 consumption from dietary sources attributes to less arterial calcification and reduced risk of coronary heart disease.

Researchers at the R&D Group VitaK of Maastricht University in the Netherlands monitored 244 healthy post-menopausal women for three years using pulse wave velocity and ultrasound techniques. The participants, aged 55-65 years, were randomly assigned to take 180 mcg of MenaQ7 daily for three years, or placebo capsules. Results confirmed that MenaQ7 Vitamin K2 not only inhibited age-related stiffening of the artery walls, but also made an unprecedented statistically significant improvement of vascular elasticity.

To review the “Statin” study online prior to publication, visit http://www.ncbi.nlm.nih.gov/pubmed/25655639.

The cardiovascular study appears in the May 2015 issue of Thrombosis and Haemostasis. To review online, visit http://th.schattauer.de/en/contents/current-issue/issue/special/manuscript/24032/show.html.

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About NattoPharma and MenaQ7®

NattoPharma develops and sells vitamin K2 including preventive effect against osteoporosis and cardiovascular disease. The company builds its competitive advantage with clinical research, patents, and rights, as well as strong sales and marketing efforts, and its MenaQ7® brand is the only clinically validated vitamin K2 on the market. NattoPharma has exclusive rights to sell and market the brand MenaQ7® Vitamin K2 as MK-7 globally and offers its vitamin K2 products as ingredients in dietary supplements, functional food, and medical food. The company is also in the process of developing a pharmaceutical product candidate.

Contact:

Hogne Vik, NattoPharma CEO

E-mail: hogne.vik@nattopharma.com

OR

Kate Quackenbush, NattoPharma Director of Communications

E-mail: kate.quackenbush@nattopharma.com

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About Us

NattoPharma, the world leader in Vitamin K2 Research and Development, has invested millions of dollars in in-vitro, in-vivo, and clinical studies to document the effects of MenaQ7® Vitamin K2 as MK-7. This commitment has created the only patented and clinically validated K2 on the market. After establishing the first commercial Vitamin K2 with its flagship brand, MenaQ7®, NattoPharma has consistently answered and met market needs through the development of new production technologies:• In 2012, the company introduced MenaQ7® Crystals, which represented an important breakthrough in the new generation of Vitamin K2 products, producing the purest natural MK-7 available.• In 2014, NattoPharma introduced the only all-trans nature-identical synthesized Vitamin K2, MenaQ7® PURE. Not only did the company succeed in changing the market with MenaQ7® PURE – offering a high-quality, competitively priced ingredient – but its efforts were rewarded with the NutrAward for Best Functional Ingredient at Natural Products West/engredea 2015. Vitamin K2 is essential for the body to utilize calcium to build healthy, strong bones and to inhibit calcium deposits in the arteries. Published clinical studies have demonstrated the high bioavailability and proof of efficacy for Nattopharma’s all-trans MK-7 products in healthy and diseased populations, for bone and cardiovascular health. NattoPharma continues to build its competitive advantage through focuson IPR and has patents both granted and pending related to relevant healthbenefits and market segments, creating extra value for its customers. And NattoPharma staff consists of professionals people with longstanding experience in medical and biochemical research as well as pharmaceutical and food supplement development. By understanding and controlling the chemistry, NattoPharma provides the market all-trans MK-7 products, while our sales and marketing team has extensive knowledge of international market demands with which it supports our partners.