Nuevolution to present new data on its BET BD1 program supporting the understanding of the biological mode-of-action

Stockholm, 27 October 2017. Nuevolution AB (publ) (NUE.ST) today announced that Søren Jensby Nielsen, Director of Biology, will be presenting new data on Nuevolution’s selective bromodomain BET BD1 inhibitor at the 5th Annual Meeting of the Cytokine and Interferon Society, held 29 October - 2 November in Kagasawa, Japan.

At the conference, new data on Nuevolution’s selective bromodomain BET BD1 inhibitor, NUE7770, will be presented. This includes gene expression profiles showing selective and potent inhibition of a small and select set of immune-related genes. These data support the benign safety profile observed with Nuevolution’s BET BD1 selective inhibitors as well as propose a link between selective BET BD1 inhibition and the efficacy observed in multiple mouse disease models such as Lupus, Psoriasis and Fibrosis. The new data is expected to guide and support Nuevolution’s conclusion regarding its choice of optimal indication(s) for the further development of the program.

Dr. Jensby will be presenting these new data in the context of previously disclosed data from Nuevolution’s selective bromodomain BET BD1 selective inhibitor program (inflammation and auto-immune diseases) showing in-vitro / in-vivo efficacies and good safety data for NUE7770 and related program compounds.

The potent and BET BD1 selective compounds in this program was originally identified using Nuevolution’s proprietary Chemetics® technology, and the program is currently in pre-clinical development for potential application in multiple inflammatory and autoimmune diseases.

The presentation is available on Nuevolution’s website www.nuevolution.com.

For more information, please contact:

Thomas Franch, CSO

Phone: +45 7020 0987

Email: tf@nuevolution.com

Henrik D. Simonsen, CFO

Phone: +45 3913 0947

Email: hs@nuevolution.com 

About Chemetics™ 

The Nuevolution Chemetics™ platform technology comprises proprietary methods enabling DNA-encoding of compound libraries for fast and cost-efficient screening of disease targets. Nuevolution annually produces up to eight Chemetics™ libraries. For further details see Nuevolution homepage: www.nuevolution.com.

About Nuevolution 

Nuevolution AB (publ) is a leading small molecule drug discovery biotech company founded in 2001, headquartered in Copenhagen, Denmark. Nuevolution partners its proprietary discovery platform and programs with pharmaceutical and biotechnology companies to seek future benefit for patients in need of novel medical treatment options. Nuevolution’s internal programs are focused on therapeutically important targets within inflammation, oncology and immuno-oncology.

This information is information that Nuevolution AB (publ) is obliged to make public pursuant to the EU Market Abuse Regulation. The information was sent for publication, through the agency of the contact persons set out above, on Friday 27 October 2017, 16:00 CET.

Nuevolution AB (publ) is listed at Nasdaq First North Premier in Stockholm, Sweden (ticker: NUE.ST). Redeye AB acts as Certified Adviser to Nuevolution AB (publ). More information about Nuevolution can be found at: www.nuevolution.com. 

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Nuevolution is a biotechnology company with a unique business model, where continuous revenue generation and risk mitigation represent primary objectives. This strategy is executed by a “multiple shots at goal” approach in combination with reduced research costs, where simultaneous development of multiple programs in parallel is made possible. Nuevolution is the inventor of Chemetics®. Chemetics® is a patent protected drug discovery research platform, which enables identification of small molecule (tablet based) drug candidates much more effectively and at lower cost than what is possible by other conventional methods. Nuevolution applies its research platform for the identification and development of its own pipeline of drug candidates for treatment of cancer and chronic inflammatory diseases Nuevolution applies a business model that is unique for a biotechnology company with a primary focus on revenue generation and risk minimization (i.e. lower cost development) by having a number of programs developed in parallel. Nuevolution is the inventor of Chemetics® , a patent protected drug discovery platform which enables efficient discovery of novel chemical small molecule leads for specific indications addressing disease targets within the company’s therapeutic focus areas

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