Epirubicin-DRP™ data for Breast Cancer to be presented at ASCO

Hoersholm, Denmark, April 12th, 2017 – Oncology Venture Sweden AB (“Oncology Venture”) today announced that an abstract has been accepted for presentation at this year’s ASCO (American Society of Clinical Oncology). The title of the abstract is “Retrospective-prospective blinded evaluation predicting efficacy of epirubicin by a multigene assay in advanced breast cancer within a Danish Breast Cancer Cooperative Group (DBCG) cohort”. The poster will be presented on the 4th of June 2017 at the annual ASCO conference in Chicago, USA taking place from June 2-6 2017.

The poster will be presented on the poster session Breast Cancer—Metastatic

on the 4th of June 2017 at 8:00 AM-11:30 AM local time/15:00-18:30 CET.

The abstract will be released by ASCO

on May 17, 2017, at 5:00 PM EDT/23:00 CET on abstracts.asco.org.

ASCO, American Society of Clinical Oncology, ANNUAL MEETING. McCormick Place, Chicago, Illinois, USA.

Founded in 1964, the American Society of Clinical Oncology (ASCO) is committed to making a world of difference in cancer care. As the world’s leading organization of its kind, ASCO represents more than 40,000 oncology professionals who care for people living with cancer. The ASCO Annual Meeting is considered the premiere international forum for the presentation of scientific research and state-of-the-art education in clinical oncology. The five-day event attracts 30,000 attendees from around the world. Clinical trial results and updates presented at ASCO's Annual Meeting represent the significant progress made each year in the fight against cancer.

On the 24th of January 2017 Oncology Venture and Medical Prognosis Institute (“MPI”) published information on data from more than 800 patients with metastatic breast cancer: Data for epirubicin, fulvestrant, anastrazole and exemestan demonstrated with statistical significant values that the PRP could predict whether the individual patients responded on the treatment with the mentioned drugs or not. As there is a high number of active anticancer agents for Breast Cancer and this approach has been very fruitful Oncology Venture and MPI will continue to broaden the database and the data mining to increase the number of products where our technology can bring value to the choice of therapy. 

“Anthracyclines epirubicin and doxorubicin (almost identical drugs) are cornerstones in the treatment of all types of metastatic breast cancer. The recently in-licensed drug 2X-111 is a liposomal doxorubicin compound. The potential value of the DRP™’s to correctly predict those patients who will benefit from the 2X-111 treatment is huge. I look forward the presentation the epirubicin DRP™ data at the annual ASCO – the largest event for anticancer drug developers”, said Adjunct Professor Peter Buhl Jensen, M.D., CEO of Oncology Venture. “2X-111 will be developed in two focused Phase 2 trials in metastatic Breast Cancer and in Glioblastoma in 2X Oncology Inc. a precision medicines company for Women’s Cancers – a spinout from Oncology Venture currently 92% owned by Oncology Venture”, Peter Buhl Jensen further commented. 

For further information on Oncology Venture please contact

Ulla Hald Buhl, COO and Chief IR & CommunicationsMobile: +45 2170 1049E-mail: uhb@oncologyventure.com or Peter Buhl Jensen, CEOMobile: +45 21 60 89 22E-mail: pbj@oncologyventure.com 

About the DRP™ Companion Diagnostic

Developed by and in-licensed from Medical Prognosis Institute, the DRP™ screening platform utilizes messenger RNA (mRNA) gene expression signatures from patient biopsies to identify patients with a high likelihood of responding to specific cancer-fighting therapies. This DRP™ method builds on the comparison of sensitive vs. resistant human cancer cell lines, including genomic information from cell lines, combined with clinical tumor biology and clinical correlates in a systems biology network. Specific DRP™’s are developed for each pipeline product, which will enable us to identify and predict which patients are most likely to respond and thereby benefit from a given pipeline product.  This would enable likely responders to receive appropriate treatment while expediting the decision path for predicted non-responders, saving them critical time and money in their cancer fight. 

About Oncology Venture Sweden AB (OV)

OV is engaged in the research and development of anti-cancer drugs via its wholly owned Danish subsidiary Oncology Venture ApS. Oncology Venture has a license to use Drug Response Prediction – DRP™ – in order to significantly increase the probability of success in clinical trials. DRP™ has proven its ability to provide a statistically significant prediction of clinical outcomes from drug treatment in cancer patients in 29 of the 37 clinical studies that were examined. The Company uses a model that alters the odds in comparison with traditional pharmaceutical development. Instead of treating all patients with a particular type of cancer, patients’ tumors genes are screened first and only those who are most likely to respond to the treatment will be treated. Via a more well-defined patient group, the risk and costs are reduced while the development process becomes more efficient.

The current product portfolio: LiPlaCis for Breast Cancer in collaboration with Cadila Pharmaceuticals, Irofulven developed from a fungus for prostate cancer and APO010 – an immuno-oncology product for Multiple Myeloma.

Oncology Venture has spun out 2X Oncology Inc. a company focused on developing precision medicine for women’s cancer with three anticancer products in pipeline and OV-SPV2 which will test and potentially develop an oral Tyrosine Kinase inhibitor from a Big Pharma the treatment of cancers.


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