Narcolepsy study finds surprising increase in neurons that produce histamine
Novel findings may have therapeutic implications for this potentially disabling sleep disorderDARIEN, IL – A new study provides surprising evidence that people with narcolepsy have an increased number of neurons that produce histamine, suggesting that histamine signaling may be a novel therapeutic target for this potentially disabling sleep disorder. “The orexin/hypocretin neuropeptides promote wakefulness, and researchers have known for 13 years that narcolepsy is caused by loss of the orexin/hypocretin neurons in the hypothalamus,” said principal investigator Thomas Scammell, MD,