Optimal Clearing Method for Quick Tissue Recovery

High Precision Targeted Micro-Dissection Demonstrated at Unreported Levels

Wausau, WI – Research conducted by Jinze Qiu, Ph.D., Joseph Neev, Ph.D., Tianyi Wang, Ph.D., and Thomas E. Milner, Ph.D., was selected as Editor’s Choice in the August issue of Lasers in Surgery and Medicine (LMS), the official journal of the American Society for Laser Medicine and Surgery, Inc. (ASLMS).

The published manuscript is titled “Deep Subsurface Cavities in Skin Utilizing Mechanical Optical Clearing and Femtosecond Laser Ablation”. “Although light can be focused deep in transparent tissues such as the eye, strong light scattering of many tissues such as skin prohibits deep light delivery,” commented Dr. Qiu. Dr. Qiu is currently a senior scientist at Candela Corporation and developing new laser technologies for a diverse range of aesthetic treatments such as facial pigment removal and vascular treatment. He has developed a 1940nm laser for pigment removal. 

“The mechanical optical clearing method is easy to implement and allows for quick tissue recovery, making the approach practical in the clinic,” explains Dr. Neev. Dr. Neev is presently the president and CEO of Femto-Sec Tech, Inc., a California company.  He has authored over 80 publications in peer-reviewed literature, and is the inventor or co-inventor of 14 patents and numerous patent applications. 

“Using Femtosecond laser pulses, we were able to demonstrate high precision targeted micro-dissection in rodent skin at depths up to 1.7 millimeters, almost ten times deeper than previously reported,” said Dr. Milner. Dr. Milner currently holds the Marion E. Forsman Centennial Professorship in the College of Engineering.  He is also an Adjunct Professor in the Departments of Ophthalmology at the University of Texas Medical Branch in Galveston and the Health Sciences Center in San Antonio.  He has authored over 150 publications in peer-reviewed literature and co-invented over 30 issued patents.

“This is the first demonstration of precise non-invasive micro-dissection of deep skin components by Femtosecond laser pulses. The technique, if fully developed, can be used practically for surgical procedures that require precise non-invasive micro-dissection of tissue components,” stated Dr. Wang. Dr. Wang is currently a research associate in the Department of Biomedical Engineering at the University of Texas at Austin.  His research area includes laser-based imaging system design, modeling and image processing, specifically in thermal imaging, optical coherence tomography, multi-photon luminescence imaging, 3-D modeling of light/heat transfer in tissue and medical image processing.

J. Stuart Nelson, M.D., Ph.D., Editor-in-Chief of LSM, commented on the research, “Although femtosecond lasers are frequently utilized in ophthalmologic refractive correction and cataract surgical procedures, applications in highly scattering tissues such as skin are unavailable.  In the article, Qiu et al report a methodology demonstrating non-invasive precise subsurface micro-dissection in skin over the full thickness.  Development of the methodology can establish a novel class of laser surgical procedures that can target modifications to any cell, endogenous or exogenous tissue structure, to achieve a broad range of desired therapeutic outcomes.”

Editor’s Choice is an exclusive article published in Lasers in Surgery and Medicine, the official journal of ASLMS.  To view the complete manuscript, visit www.aslms.org, select “Laser Education” followed by “LSM – Editor’s Choice”.

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The American Society for Laser Medicine and Surgery, Inc. (ASLMS) is the world's largest scientific organization dedicated to promoting research, education and high standards of clinical care in the field of medical laser applications. It provides a forum for the exchange of scientific information and participates in communicating the latest developments in laser medicine and surgery to clinicians, research investigators, government and regulatory agencies, and the public.

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