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Extensive new preclinical study significantly increases the Translatability of Asarina Pharma’s findings on key stress mechanism implicated in Tourette Syndrome and OCD

(Stockholm, 6 October 2022.) A new study in the journal Neurobiology of Stress reconfirms the central role the neurosteroid Allopregnanolone (ALLO) plays in stress-related conditions such as Tourette syndrome and OCD, and the efficacy of its endogenous modulator isoallopregnanolone in modulating its negative effects. This is the most extensive of four preclinical studies confirming these findings, significantly increasing the Translatability of data. Asarina Pharma is testing isoallopregnanolone (under the name Sepranolone) for Tourette syndrome in a Phase IIa study, with the last patient

Asarina Pharma AB (publ) Q2 2022 Report released

CEO Peter Nordkild: “We are pleased to report continued progress in our Phase II study in Sepranolone for the treatment of Tourette in the second quarter of 2022. With more than two thirds of patients recruited and a drop-out rate of under 5%, the study remains fully funded, and we remain confident of reporting topline results by the end of Q1 2023.”FINANCIAL HIGHLIGHTS · Total operating costs have been further reduced to SEK 4.0 million (Q2/2021: SEK 16.0 million.) This reflects that all resources are now being allocated to our phase IIa study in Tourette · Present funding still

Asarina Pharma AB (publ) Year-end Report 2021 released

Peter Nordkild, CEO: “We enter the new financial year with renewed energy and optimism after Region Hovedstaden finally signed the required papers for our clinical test sites in Copenhagen, and we achieved ‘First Patient First Visit’ on 16 February in our phase IIa clinical study in Tourette syndrome. We are now moving ahead confidently in our search to develop a safer, entirely novel modality of treatment for Tourette syndrome, and, potentially, OCD.”FINANCIAL HIGHLIGHTS · Total operating expenses in Q4/21 reduced to 8.7 MSEK (24.9 MSEK in Q4/20) · Cash balance at 31 December 2021

First patient in for landmark Tourette Syndrome study

(Stockholm, 16 February, 2022.) Asarina Pharma announces today that ‘First Patient First Visit’ has taken place in its phase IIa clinical study in Tourette syndrome at Bispebjerg University Hospital, Copenhagen. The Asarina compound being trialled, Sepranolone, is an endogenous neurosteroid that has already demonstrated a strong safety profile in previous clinical studies. In preclinical studies it was found to reduce tics effectively without inducing any motor side effects. Today’s pharmaceutical treatments for Tourette, such as the anti-psychotic Haldol, involve multiple severe side effects.

Asarina Pharma AB (publ) Q3 Report 2021 released

Asarina Pharma CEO Peter Nordkild: “While we made progress in several areas during Q3 2021, it was frustrating for us that our phase IIa study in Tourette Syndrome was delayed. We now expect our first patients to be included in the Study in December.”FINANCIAL HIGHLIGHTS · Significant reduction in operating costs in Q3 · Cash position on 30 September 2021 (SEK 23.5 million) still expected to cover the Tourette study R&D HIGHLIGHTS · TOURETTE SYNDROME Following an administrative delay from Region Hovedstaden (the Capital Region of Denmark) we expect to receive final legal

Asarina Pharma AB (publ) Q2 Report 2021 released

Asarina Pharma CEO Peter Nordkild: “Q2 2021 was a difficult quarter for us and our shareholders. It was also a definitively transformative one. The failure of our Phase IIa study in Menstrual Migraine coincided with the approval of our CTA in Tourette syndrome by the Danish Medicines Agency, and the granting of our first US patent for Sepranolone for the treatment of Tourette, OCD and pathological gambling. Together, these developments signal the end of an important chapter in our history, and the beginning of a new journey.”FINANCIAL HIGHLIGHTS · Operating costs (SEK 16.0 million)

Asarina Pharma granted US patent for Sepranolone for Tourette syndrome, OCD and pathological gambling

(Stockholm, 8 June 2021.) The US Patent and Trademark Office has granted a patent for Sepranolone for the treatment of Tourette, Obsessive-Compulsive Disorder (OCD) and pathological gambling. CEO Peter Nordkild: “The powerful neurosteroid Allopregnanolone (ALLO) seems to be the missing link in a raft of stress-related disorders, from Tourette to OCD, characterized by tics and compulsions. Sepranolone is essentially patented isoallopregnanolone, the endogenous compound that inhibits ALLO. This patent confirms Sepranolone’s enormous clinical potential.”The new patent is valid until 2038.

Asarina Pharma obtains convertible loan for continued research on neurological conditions including Obsessive Compulsive Disorder

(Stockholm, 31 May 2021) Asarina Pharma AB (publ) has obtained a convertible loan of 5.3 MSEK from Östersjöstiftelsen (ÖSS), one of its key shareholders, for ongoing and upcoming R&D into neurological disorders including OCD (Obsessive Compulsive Disorder).The convertible loan supplements Asarina Pharma’s current financial resources and will be spent on further exploration of the potential of Sepranolone within neurological diseases. The loan carries an interest rate of 10% p.a. and the maturity date is 30 June 2023. ÖSS has the right at any time before maturity to convert the loan to

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