Director/PDMR Shareholding

Transaction by Person Discharging Managerial Responsibilities
Disclosure Rule DTR 3.1.4

On 23 May 2016, the interest of Luke Miels, a person discharging managerial responsibilities, in AstraZeneca PLC Ordinary Shares of $0.25 each changed as detailed below.

The change in interest relates to the vesting on 23 May 2016 of an award of shares granted in September 2014 under the AstraZeneca Restricted Share Plan. In accordance with the terms of the award, Mr Miels has become beneficially entitled to all of the shares originally awarded.

Sufficient vested shares have been withheld to cover certain tax obligations arising on the vesting and the net number of shares has been delivered into a personal brokerage account.

For tax purposes, the fair market value of the shares at vest was 3894.5 pence per share being the closing price of AstraZeneca shares on the last trading day preceding the vesting day.

A C N Kemp
Company Secretary
23 May 2016