Director/PDMR Shareholding

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12 June 2024

Transaction by Person Discharging Managerial Responsibilities

AstraZeneca PLC (the Company) announces that, on 10 June 2024, it was notified by Pascal Soriot, Chief Executive Officer, that, on 10 June 2024, Mr Soriot ceased to be beneficially interested in 297,418 Ordinary Shares of $0.25 each in the Company, following the gift of those shares to family members for nil consideration.

Further details are set out in the attached notification, made in accordance with the requirements of the EU Market Abuse Regulation (as it forms part of UK law pursuant to the European Union (Withdrawal) Act 2018).

1 Details of the person discharging managerial responsibilities / person closely associated
a) Name Pascal Soriot
2 Reason for the notification
a) Position/status Chief Executive Officer
b) Initial notification /Amendment Initial notification
3 Details of the issuer, emission allowance market participant, auction platform, auctioneer or auction monitor
a) Name AstraZeneca PLC
b) LEI PY6ZZQWO2IZFZC3IOL08
4 Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each type of transaction; (iii) each date; and (iv) each place where transactions have been conducted
a) Description of the financial instrument, type of instrumentIdentification code Ordinary Shares of US$0.25 each in AstraZeneca PLCGB0009895292
b) Nature of the transaction Gift of shares to family members for nil consideration
c) Price(s) and volume(s)
Price(s) Volume(s)
0 297,418
d) Aggregated information- Aggregated volume- Price Not applicable - single transaction
e) Date of the transaction 10 June 2024
f) Place of the transaction Outside a trading venue

AstraZeneca

AstraZeneca (LSE/STO/Nasdaq: AZN) is a global, science-led biopharmaceutical company that focuses on the discovery, development, and commercialisation of prescription medicines in Oncology, Rare Diseases, and BioPharmaceuticals, including Cardiovascular, Renal & Metabolism, and Respiratory & Immunology.

Based in Cambridge, UK, AstraZeneca's innovative medicines are sold in more than 125 countries and used by millions of patients worldwide. Please visit astrazeneca.com and follow the Company on social media @AstraZeneca.

Contacts

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Adrian Kemp
Company Secretary

AstraZeneca PLC

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