Director/PDMR Shareholding

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Transaction by Persons Discharging Managerial Responsibilities

Disclosure Rule DTR 3.1.4

The following individuals, who are all Directors of the Company, have notified us that they have purchased AstraZeneca PLC Ordinary Shares of $0.25 each or AstraZeneca American Depositary Shares (ADSs).

One AstraZeneca ADS equals one AstraZeneca PLC Ordinary Share of $0.25.

Name of Director Date of notification Date of purchase Number of shares purchased Purchase price
Bruce Burlington 28 April 2015 27 April 2015 600 $71.03
Graham Chipchase 28 April 2015 28 April 2015 1,100 4606p
Shriti Vadera 29 April 2015 29 April 2015 3,500 4563p

A C N Kemp

Company Secretary

29 April 2015

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