Director/PDMR Shareholding

Transaction by Person Discharging Managerial Responsibilities

Disclosure Rule DTR 3.1.4

On 28 August 2015, Pascal Soriot, a Director of the Company, notified us that, on 25 August 2015, he purchased 76,300 AstraZeneca PLC Ordinary Shares of $0.25 each at a price of 3960 pence per share.

Mr Soriot intends to gift the shares to family members.

A C N Kemp

Company Secretary

28 August 2015