Director/PDMR Shareholding

Transactions by Person Discharging Managerial Responsibilities
Disclosure Rule DTR 3.1.4

On 25 September 2015, Dr Sean Bohen, EVP, Global Medicines Development & Chief Medical Officer, a person discharging managerial responsibilities, was granted awards under the terms of the AstraZeneca Performance Share Plan (AZPSP) and the AstraZeneca Restricted Share Plan (AZRSP) over the Company's American Depositary Shares (ADSs). Two ADSs equal one Ordinary Share of US$0.25 each.

Name ADSs   awarded under AZPSP ADSs   awarded under AZRSP Award   price per ADS
Sean   Bohen 16,003 51,802 $32.32

The AZPSP award is subject to a combination of performance measures focused on AstraZeneca's scientific, commercial and financial performance assessed over a three-year performance period (1 January 2015 to 31 December 2017). The award will vest on the third anniversary of the date on which it was granted.

The AZRSP award will vest, subject to Dr Bohen's continued employment with the Company, as follows:

25,901 ADSs will vest on 25 September 2016
25,901 ADSs will vest on 25 September 2017

A C N Kemp
Company Secretary
28 September 2015


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AstraZeneca is a global, innovation-driven biopharmaceutical business with a primary focus on the discovery, development and commercialisation of prescription medicines. As a leader in gastrointestinal, cardiovascular, neuroscience, respiratory and inflammation, oncology and infectious disease medicines, AstraZeneca generated global revenues of US $32.8 billion in 2009. For more information please visit:


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