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TR-1:   NOTIFICATION OF MAJOR INTEREST IN SHARESi
1. Identity of the issuer or the   underlying issuer of existing shares to which voting rights are attached:ii AstraZeneca PLC
2 Reason for the notification (please tick the   appropriate box or boxes):
An acquisition or disposal of voting rights Yes
An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached No
An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments No
An event changing the breakdown of voting rights No
Other (please pecify):
3. Full name of person(s) subject to   the
  notification obligation: iii		 Invesco Limited
4. Full name of shareholder(s)
  (if different from 3.):iv
5. Date of the transaction and date   on
  which the threshold is crossed or
  reached:   v		 17 April 2014
6. Date on which issuer notified: 17 June 2014
7. Threshold(s) that is/are crossed   or
  reached: vi,   vii		 5%
8. Notified details:
A: Voting rights attached to shares viii, ix
Class/type of
shares		 Situation previous
to the triggering
transaction		 Resulting situation   after the triggering transaction
if possible using
the ISIN CODE		 Number
of
Shares		 Number
of
Voting		 Number
of shares		 Number of voting
rights		 % of voting rights x
Rights Direct Direct xi Indirect xii Direct Indirect
Ordinary Shares
   
GB0009895292		 72,920,319 72,920,319 63,033,761 4.99%
B: Qualifying Financial Instruments
Resulting situation   after the triggering transaction
Type of financial
instrument		 Expiration
date xiii		 Exercise/  Conversion Period xiv Number of voting
rights that may be
acquired if the
instrument is
exercised/ converted.		 % of voting
rights
C: Financial Instruments with   similar economic effect to Qualifying Financial Instruments xv, xvi
Resulting situation   after the triggering transaction
Type of financial
instrument		 Exercise price Expiration date xvii Exercise/
Conversion period xviii		 Number of voting   rights instrument refers to % of voting rights xix, xx
Nominal Delta
Total (A+B+C)
Number of voting   rights Percentage of   voting rights
63,033,761 4.99%
9. Chain of controlled undertakings   through which the voting rights and/or the
  financial instruments are effectively held, if applicable: xxi
Invesco Advisers Inc. – 182,047
Invesco Asset Management Japan – 75,034
Invesco Asset Management Limited – 16,790,150
Invesco Asset Management S.A (France) – 76,196
Invesco PowerShares Capital Management LLC – 158,278
Invesco GT Management Ltd – 39,146
Invesco Hong Kong Limited – 1,155
Invesco Fund Managers Limited – 45,006,926
Invesco Asset Management Limited GmbH – 667,087
Van Kampen Asset Management – 37,742
Proxy Voting:
10. Name of the proxy holder: Invesco Limited
11. Number of voting rights proxy holder will cease
  to hold:		 N/A
12. Date on which proxy holder will cease to hold
  voting rights:		 N/A

13. Additional information:		  
 
14. Contact name: Sam Edwards
15. Contact telephone number: 01491 416381

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