REPURCHASE OF SHARES IN ASTRAZENECA PLC

AstraZeneca PLC announced that on 18 May 2011, it purchased for cancellation  235,115 ordinary shares of AstraZeneca PLC at a price of  3183 pence per share.

Some of these shares were purchased under the terms of the previously announced irrevocable, non-discretionary share repurchase programme for the period 9 May 2011 to 26 August 2011.

Upon the cancellation of these shares, the number of shares in issue will be  1,382,706,390.

A C N Kemp
Company Secretary
19 May 2011

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