REPURCHASE OF SHARES IN ASTRAZENECA PLC

AstraZeneca PLC announced that on 31 May 2011, it purchased for cancellation 440,431 ordinary shares of AstraZeneca PLC at a price of 3177 pence per share.

Some of these shares were purchased under the terms of the previously announced irrevocable, non-discretionary share repurchase programme for the period
9 May 2011 to 26 August 2011.

Upon the cancellation of these shares, the number of shares in issue will be 1,378,708,472.

A C N Kemp
Company Secretary
1 June 2011

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