REPURCHASE OF SHARES IN ASTRAZENECA PLC

Further to the announcement of its irrevocable, non-discretionary share repurchase programme for the period 9 May 2011 to 26 August 2011, AstraZeneca PLC announced that under the terms of that programme it purchased for cancellation 142,204 ordinary shares of AstraZeneca PLC at a price of 3024 pence per share on 27 July 2011. Upon the cancellation of these shares, the number of shares in issue will be 1,364,135,062.

A C N Kemp

Company Secretary

28 July 2011

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