REPURCHASE OF SHARES IN ASTRAZENECA PLC

AstraZeneca PLC announced that on 4 August 2011, it purchased for cancellation 754,366 ordinary shares of AstraZeneca PLC at a price of 2765 pence per share.

Some of these shares were purchased under the terms of the previously announced irrevocable, non-discretionary share repurchase programme for the period 9 May 2011 to 26 August 2011.

Upon the cancellation of these shares, the number of shares in issue will be 1,360,721,247.

A C N Kemp
Company Secretary
5 August 2011