REPURCHASE OF SHARES IN ASTRAZENECA PLC

Further to the announcement of its irrevocable, non-discretionary share repurchase programme for the period 3 October 2011 to 19 December 2011, AstraZeneca PLC announced that under the terms of that programme it purchased for cancellation 510,092 ordinary shares of AstraZeneca PLC at a price of 2923 pence per share on 15 December 2011. Upon the cancellation of these shares, the number of shares in issue will be 1,295,262,949.

A C N Kemp

Company Secretary

16 December 2011

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