REPURCHASE OF SHARES IN ASTRAZENECA PLC

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Further to the announcement of its irrevocable, non-discretionary share repurchase programme for the period 20 December 2011 to 2 February 2012, AstraZeneca PLC announced that under the terms of that programme it purchased for cancellation 484,039 ordinary shares of AstraZeneca PLC at a price of 2960 pence per share on 28 December 2011. Upon the cancellation of these shares, the number of shares in issue will be 1,292,339,473.

A C N Kemp
Company Secretary
29 December 2011

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