REPURCHASE OF SHARES IN ASTRAZENECA PLC

Further to the announcement of its irrevocable, non-discretionary share repurchase programme for the period 20 December 2011 to 2 February 2012, AstraZeneca PLC announced that under the terms of that programme it purchased for cancellation 476,584 ordinary shares of AstraZeneca PLC at a price of 3007 pence per share on 5 January 2012. Upon the cancellation of these shares, the number of shares in issue will be 1,290,989,415.

A C N Kemp

Company Secretary

6 January 2012

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