REPURCHASE OF SHARES IN ASTRAZENECA PLC

Further to the announcement of its irrevocable, non-discretionary share repurchase programme for the period 20 December 2011 to 2 February 2012, AstraZeneca PLC announced that under the terms of that programme it purchased for cancellation 469,709 ordinary shares of AstraZeneca PLC at a price of 3050 pence per share on 13 January 2012. Upon the cancellation of these shares, the number of shares in issue will be 1,288,181,254.

A C N Kemp

Company Secretary

16 January 2012

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