REPURCHASE OF SHARES IN ASTRAZENECA PLC

AstraZeneca PLC announced that on 3 February 2012, it purchased for cancellation 678,799 ordinary shares of AstraZeneca PLC at a price of 2992 pence per share.

Some of these shares were purchased under the terms of the previously announced irrevocable, non-discretionary share repurchase programme for the period 20 December 2011 to 8 February 2012.

Upon the cancellation of these shares, the number of shares in issue will be 1,281,741,232.

A C N Kemp

Company Secretary

6 February 2012

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