REPURCHASE OF SHARES IN ASTRAZENECA PLC

Further to the announcement of its irrevocable, non-discretionary share repurchase programme for the period 20 December 2011 to 8 February 2012, AstraZeneca PLC announced that under the terms of that programme it purchased for cancellation 478,287 ordinary shares of AstraZeneca PLC at a price of 2997 pence per share on 6 February 2012. Upon the cancellation of these shares, the number of shares in issue will be 1,281,295,585.

A C N Kemp

Company Secretary

7 February 2012

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