REPURCHASE OF SHARES IN ASTRAZENECA PLC

Further to the announcement of its irrevocable, non-discretionary share repurchase programme for the period 5 March 2012 to 11 May 2012, AstraZeneca PLC announced that under the terms of that programme it purchased for cancellation 296,824 ordinary shares of AstraZeneca PLC at a price of 2867 pence per share on 14 March 2012. Upon the cancellation of these shares, the number of shares in issue will be 1,274,100,316.

A C N Kemp

Company Secretary

15 March 2012

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