REPURCHASE OF SHARES IN ASTRAZENECA PLC

Further to the announcement of its irrevocable, non-discretionary share repurchase programme for the period 5 March 2012 to 11 May 2012, AstraZeneca PLC announced that under the terms of that programme it purchased for cancellation 305,437 ordinary shares of AstraZeneca PLC at a price of 2785 pence per share on 30 March 2012. Upon the cancellation of these shares, the number of shares in issue will be 1,273,493,566.

A C N Kemp

Company Secretary

2 April 2012

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