REPURCHASE OF SHARES IN ASTRAZENECA PLC

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AstraZeneca PLC announced that on 15 May 2012, it purchased for cancellation 550,000 ordinary shares of AstraZeneca PLC at a price of 2654 pence per share. Upon the cancellation of these shares, the number of shares in issue will be 1,266,580,309.

A C N Kemp

Company Secretary

16 May 2012

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