New publication - Attana’s technology was used to optimize affinity and efficacy of an antibody fragment for treatment of inflammatory diseases
A new paper has been published in mAbs by Prof. Konterman and co-workers at University of Stuttgart. This work is in the same project as the recent publication.The aim of this study was to extended serum half-life, increase affinity and improved efficacy. Attana's QCM technology was used to optimize the specific interaction properties of the antibody fragment.
Tumor necrosis factor (TNF) plays a central role in the immune system, especially during inflammation and infection. Dysregulated expression of TNF is associated with severe inflammatory conditions and has been reported to be involved in the development of diseases such as type II diabetes, Crohn’s disease and rheumatoid arthritis.
In this study Prof. Kontermann and coworkers applied affinity maturation and re-engineering of humanized variable domains to generate a panel of monovalent Fab derivatives. In order to improve pharmacokinetic properties, several Fab-derived molecules were generated, including a PEGylated Fab, a mouse serum albumin fusion protein, a half-IgG with a dimerization-deficient Fc, and a newly designed Fv-Fc format. Among these derivatives, one displayed the best combination of improved pharmacokinetic properties and antagonistic activity, thus representing a promising candidate for further clinical development. Attana´s QCM technology has been used to characterize the interaction to select and optimize the most potent Fab-molecule.
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