First time in man-AMPK activator O304

Betagenon AB/Baltic Bio AB announces the initiation of Phase I clinical studies with O304, an orally available AMPK activator.The epidemic increase in obesity has generated a concomitant increase in fatty liver, non-alcoholic steato-hepatitis (NASH) and type 2 diabetes (T2D). Physical inactivity and T2D in elderly are in turn strongly associated with peripheral arterial disease (PAD), caused by reduced blood flow to the legs. Several 100 millions of patients globally live with NASH, T2D or PAD. There are very limited therapeutic options for NASH and PAD, and few new innovative drugs to