A bacterial cell is simultaneously attacked by antibiotics and a bactericidal material


Photographer: Illustration: Annija Stepulane/International Journal of Pharmaceutics

A bacterial cell (left) is simultaneously attacked on two fronts: by antibiotics and by a positively charged, bactericidal peptide-based material that disrupts the structure of the bacteria’s negatively charged cell membranes. A study from Chalmers University of Technology demonstrates that this combination yields an efficacy far greater than the sum of the individual effects of the antibiotic and the material. This article is available under the terms of the Creative Commons Attribution License (CC BY): https://creativecommons.org/licenses/by/4.0/ This article was published in International Journal of Pharmaceutics, Volume 664, Annija Stepulane, Anand Kumar Rajasekharan, Martin Andersson, Antibacterial efficacy of antimicrobial peptide-functionalized hydrogel particles combined with vancomycin and oxacillin antibiotics, Copyright Elsevier, 2024.

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Chalmers University of Technology in Gothenburg conducts research and education in technology and natural sciences at a high international level. The university has 3100 employees and 10,000 students, and offers education in engineering, science, shipping and architecture. With scientific excellence as a basis, Chalmers promotes knowledge and technical solutions for a sustainable world. Through global commitment and entrepreneurship, we foster an innovative spirit, in close collaboration with wider society.Chalmers was founded in 1829 and has the same motto today as it did then: Avancez – forward. --- Images provided in Chalmers University of Technology press releases are, unless specified otherwise, free for download and publication as long as credit is given to the University and the individual creator. Cropping and rescaling of the images is permitted when required for adaptation to the publication’s format, but modifications that would influence the message and content of the original are not. The material is primarily intended for journalistic and informative use, to assist in communication and coverage of Chalmers’ research and education. Commercial usage, for example the marketing of goods and services, is not permitted. We kindly request credit to be given in the following format where possible: Image/Graphic/Illustration: Chalmers University of Technology | Name Surname

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