CAP Member Discusses Advance Lung Cancer Testing in Oncology Journal

Nirali M. Patel and a Colleague Discuss the IssueDR. PATEL: Multiple factors can affect the ability to characterize a patient’s tumor for the purpose of supporting targeted therapy decisions. There are a variety of lab tests that can determine whether tumors have gene alterations that are targets for therapy. EGFR mutations span 4 exons of the gene and are often classified using Sanger sequencing and/or real-time polymerase chain reaction (PCR)-based assays. Although Sanger sequencing detects all changes within this region, it has a lower limit of detection of approximately 20% mutant