ExpreS2ion announces U.S. patent issue notification for glyco-engineered immunization antigens
Hørsholm, Denmark, 3 July 2024 – ExpreS2ion Biotech Holding AB’s affiliate ExpreS2ion Biotechnologies ApS (“ExpreS2ion") a late preclinical stage biotechnology company with a focused portfolio of vaccine candidates targeting infectious diseases and cancer, today announced it has received an Issue Notification from the United States Patent and Trademark Office (USPTO) for the patent "Glyco-Engineered Immunization Antigens”. Granting of the patent in the U.S. validates the patentability of ExpreS2ion’s technology platform patent portfolio, thus representing a significant value inflection point for the company.
Although the mechanism of action may differ, we have demonstrated that altering the surface properties of select vaccine candidates can enhance the immune response in animals to levels previously achieved only through nanoparticle presentation of the vaccine protein. We are continuing to investigate both the underlying mechanisms and other proof-of-concept applications of glycomodification.
Dr. Max Soegaard, Senior Vice President R&D and Technology comments:
“We are now witnessing the outcomes of our continuous efforts to enhance and expand the capabilities of our proprietary platform. Through our R&D, we have succeeded in improving not only the quantity but also the features of proteins expressed for vaccine purposes. This patent is a significant testament to the team's dedication, and I am excited to see it come to fruition”
About glycoengineering in Drosophila S2 cells and the prospects
By modifying specific biochemical pathways in our Drosophila S2 cell lines, we enable them to alter the surface properties of the proteins they produce. These modifications can significantly enhance the immune response to a protein, making the resulting vaccine much more effective while also reducing production costs. We are continually developing these GlycoX-S2 cell lines to further refine the ExpreS2™ system's full potential for creating novel vaccines. In June 2024, we presented the use of glycoengineered Drosophila S2 cells for production of highly immunogenic antigens - see news.
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For further information about ExpreS2ion, please contact:
Bent U. Frandsen, CEO
Keith Alexander, CFO
Email: investor@expres2ionbio.com
About ExpreS2ion
ExpreS2ion is a biotechnology company that develops innovative vaccines for a healthier world. We want to transform healthcare by developing novel vaccines, that are life-saving and improving quality of life across the world. ExpreS2ion has developed the unique human clinical Phase III-validated technology platform, ExpreS2™, for fast and efficient development and production of the active material in vaccines. The platform, under the brand GlycoX-S2™, includes functionally modified glycosylation variants for enhanced immunogenicity and pharmacokinetics. Since 2010, ExpreS2ion has produced more than 500 proteins and virus-like particles (VLPs) in collaboration with leading research institutions and companies. ExpreS2ion develops novel VLP based vaccines in association with AdaptVac ApS, of which ExpreS2ion owns 34%. For additional information, please visit www.expres2ionbio.com.