Rights issue subscription period ending 12 April 2023; subscription possible via form

NOT FOR RELEASE, DISTRIBUTION OR PUBLICATION IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, WITHIN OR TO THE UNITED STATES, AUSTRALIA, CANADA, HONG KONG, JAPAN, NEW ZEALAND, SOUTH AFRICA, SOUTH KOREA, SWITZERLAND OR IN ANY OTHER JURISDICTION WHERE SUCH RELEASE, DISTRIBUTION OR PUBLICATION WOULD BE UNLAWFUL OR WOULD REQUIRE REGISTRATION OR ANY OTHER MEASURES. FOR MORE INFORMATION, SEE THE SECTION IMPORTANT INFORMATION BELOW.

Hørsholm, Denmark, 11 April 2023 – On 3 March 2023, the Board of Directors of Expres2ion Biotech Holding AB (“ExpreS2ion” or the “Company”) resolved, conditional upon approval from the extraordinary general meeting, to carry out a new issue of units consisting of shares and warrants of series TO8 (“Units”) with preferential rights for the Company’s existing shareholders (the “Rights Issue”). On 23 March 2023, the extraordinary general meeting approved the Board of Directors' resolution to carry out the Rights Issue. The Company will upon full subscription of the Rights Issue receive gross proceeds of approximately SEK 102.4 million. The Board of Directors of ExpreS2ion has in connection with the Rights Issue, and prior to the subscription period, which commenced on 29 March 2023, prepared a prospectus. The prospectus has been published on the Company's website and is available in Swedish and English. The subscription period will end tomorrow, 12 April 2023.

Subscription is possible via subscription form and some banks and brokers’ websites

It is possible to subscribe via the subscription form found on ExpreS²ion’s investor website, as well as digitally via Vator Securities’ website under ‘Offers.’

• https://investor.expres2ionbio.com/rights-issue-2023/
• https://vatorsecurities.se/sv/emissioner/expres2ion-biotech-holding/

Some banks and brokers no longer offer subscription via their websites. The subscription form will be available the entire subscription period.

Publication of the prospectus

For complete information about the Rights Issue, please refer to the prospectus that has been prepared by the Company and that has been approved by the SFSA. The prospectus is available in Swedish and English on ExpreS²ion’s website (https://investor.expres2ionbio.com/) and is also available on the SFSA's website (https://fi.se/sv/vara-register/prospektregistret/). The prospectus has been passported to Denmark and is thus also available for Danish investors.

The Rights Issue in brief

• The subscription price has been set to SEK 4.90 per Unit, which corresponds to SEK 4.90 per share. The warrants of series TO 8 are issued free of charge. Upon full subscription in the Rights Issue, the Company will receive initial proceeds of approximately SEK 102.4 million before deduction of issue costs. If all warrants of series TO 8 issued in the Rights Issue are exercised for the subscription of shares at an exercise price corresponding to the subscription price in the Rights Issue, the Company will receive additional proceeds of approximately SEK 102.4 million before deduction of issue costs.

• Upon full subscription in the Rights Issue, the net proceeds from the Rights Issue will be used to (i) advance the breast cancer vaccine candidate ES2B-C001, (ii) internal technology development and (iii) pipeline expansion, incl. exploration of value-added vaccine partnerships.

• Existing shareholders in ExpreS²ion as of the record date, 27 March 2023, have received one (1) unit right for each existing share. Nine (9) unit rights entitle to subscription of five (5) Units in the Rights Issue.

• In total, a maximum of 20,892,660 Units will be issued. Each Unit consists of one (1) share and one (1) warrant of series TO 8, which means that a maximum of 20,892,660 shares and 20,892,660 warrants of series TO 8 will be issued.

• The subscription period runs from and including 29 March 2023 up until and including 12 April 2023.

• In connection with the Rights Issue, the Company has received subscription commitments amounting to approximately SEK 0.8 million, corresponding to approximately 0.8 percent of the Rights Issue, from several members of the Company's Board of Directors and management, among others the Company's CEO Bent U. Frandsen. In addition, external investors have provided guarantee commitments in accordance with customary terms for a total of approximately SEK 50.5 million, corresponding to approximately 49.3 percent of the Rights Issue. Thus, the Company has obtained subscription and guarantee commitments of up to a total of approximately SEK 51.3 million, corresponding to approximately 50 percent of the Rights Issue.

• In connection with the Rights Issue, all members of the Company's Board of Directors and management with shareholdings in ExpreS²ion have undertaken towards Vator Securities AB, subject to customary exceptions, not to sell or otherwise transfer financial instruments (does not include financial instruments subscribed within the scope of the Rights Issue or thereafter) without first, in each separate case, ascertain a written approval from Vator Securities AB. The lock-up period lasts for a period of 90 days following the announcement of the outcome of the Rights Issue.

Timetable for the Rights Issue

Advisors

Vator Securities acts as financial advisor and issuing agent to the Company in connection with the Rights Issue. Advokatfirman Schjødt is the Company's legal advisor in connection with the Rights Issue.

Certified Adviser
Svensk Kapitalmarknadsgranskning AB

The information was sent for publication, through the agency of the contact persons set out above, at the time stated by the Company’s news distributor, Cision, at the publication of this press release.

For further information about ExpreS²ion Biotech Holding AB, please contact:
Bent U. Frandsen, CEO
Telephone: +45 4256 6869
E-mail: buf@expres2ionbio.com

Keith Alexander, CFO
Telephone: +45 5131 8147
E-mail: ka@expres2ionbio.com

About ExpreS2ion
ExpreS²ion Biotechnologies ApS is a fully owned Danish subsidiary of ExpreS²ion Biotech Holding AB with company register number 559033-3729. ExpreS²ion has developed a unique technology platform, ExpreS², for fast and efficient non-clinical development and production of complex proteins for new vaccines and diagnostics. ExpreS² is regulatorily validated for clinical supply. The platform includes functionally modified glycosylation variants for enhanced immunogenicity and pharmacokinetics. Since 2010, the Company has produced more than 500 proteins and virus-like particles (VLPs) in collaboration with leading research institutions and companies. ExpreS²ion develops novel VLP based vaccines in association with AdaptVac ApS, of which ExpreS²ion owns 34%. For additional information, please visit www.expres2ionbio.com.