Lytix Biopharma announces expansion of the ATLAS-IT-05 study to Europe
Oslo, 14 November 2022. Lytix Biopharma (“Lytix”) (Euronext Growth Oslo: LYTIX), a Norwegian immuno-oncology company, today announces site activation for the ATLAS-IT-05 study in three European countries.
ATLAS-IT-05 is a Phase II combination study evaluating LTX-315 and pembrolizumab in patients with advanced melanoma. The study was initiated at MD Anderson Cancer Center in 2021 and is currently ongoing in the US. The objective of the study is to document whether LTX-315 in combination with pembrolizumab is effective in inducing tumor responses in patients who have failed prior anti PD 1/PD L1 immune checkpoint therapy.
The clinical trial has now been extended to Spain, France and Norway and sites are opened in all three countries. The expansion of the site network will mitigate recruitment challenges, drive enrollment towards completion and extend the clinical impact field for LTX-315. The European branch of the study is performed at highly recognized sites with intratumoral immunotherapy expertise, led by melanoma experts at each site. It will follow the same protocol as in the US.
The regulatory application in Europe was approved in Q3 2022, and efforts to initiate recruitment of patients is ongoing with the aim to complete enrollment in the study in early 2023.
“We are very pleased to now be able to recruit patients in three European countries that will help us to complete the ongoing ATLAS-IT-05 Phase II study”, says CEO and Co-founder of Lytix Biopharma, Øystein Rekdal.
For more information, please contact:
Ole Peter Nordby, ole.peter.nordby@lytixbiopharma.com
About Lytix Biopharma AS
Based in Oslo, Norway, Lytix Biopharma is a clinical-stage biotech company developing novel cancer immunotherapies, an area within cancer therapy that is aimed at activating the patient's immune system to fight cancer. The company's technology is based on pioneering research in 'host defense peptides' – nature's first line of defense towards foreign pathogens. Lytix Biopharma's lead product, LTX-315, is a first-in-class oncolytic molecule representing a new and superior therapeutic vaccination principle to boost anti-cancer immunity, with the potential to be the ideal combination partner with other types of immunotherapies. LTX-315 targets cancer cells and disrupts their cell membranes, causing immunogenic cell death and release of a patient's tumor specific antigens and immune-stimulating molecules. This mode of action allows cytotoxic T cells to recognize, infiltrate, and attack cancer cells.
For more information, visit www.lytixbiopharma.com.
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