Medivir licenses MIV-150 to Population Council

Medivir licenses MIV-150 to Population Council MIV-150 has been outlicensed to Population Council in New York for use in a microbicide intended to prevent HIV transmission. The Population Council has previously developed Carraguard, a vaginal formulation (microbicide) which is now in clinical evaluation among women in Africa with the hope that it will decrease the risk of HIV infection and prevent other sexually transmitted diseases. Laboratory experiments indicate that the addition of MIV-150 to this vaginal formulation could substantially increase the efficacy of the formulation in preventing HIV transmission. MIV-150 is a non nucleoside inhibitor of HIV polymerase and was previously outlicensed to Chiron Corporation where it was evaluated in phase I studies. These suggested that a considerable effort would be necessary to formulate MIV-150 in order to achieve a good oral bioavailability and MIV-150 was returned to Medivir. The new use in a vaginal microbicide is not dependent on oral bioavailability but reflects the efficient binding of MIV-150 to the polymerase in the HIV particle, thus ensuring inactivation of the virus. The spread of HIV is an enormous problem in Africa and several other parts of the world. Extensive trials with vaccines have so far not been successful. An efficient vaginal microbicide preventing HIV transmission could be an important possibility for women in all countries to protect themselves against HIV. The Population Council, which is a nonprofit organization, will be responsible for the development and funding of the product. Medivir gives free access to the use of MIV-150 in the vaginal microbicide in developing countries. When used in other countries Medivir has a right to income and Medivir retains the right to the Nordic market. The Medivir Group Medivir is an innovative, specialist research corporation that develops new pharmaceutical compounds based on proteases and polymerases as target enzymes. The company is located in Huddinge, Sweden and Cambridge, UK. The group comprised Medivir AB, the subsidiaries Medivir UK Ltd. and the CCS group until 1 July 2003, after this date the CCS group is owned by Segulah II L.P. Medivir has been quoted on the Stockholm Stock Exchange since 1996 and on the Attract40 list since 1 July 2003. Medivir's research portfolio includes projects against HIV, jaundice, shingles, cold sores, osteoporosis, RA (rheumatoid arthritis), asthma and MS (multiple sclerosis). Medivir has four projects in clinical development phases, two of which are entering phase III after completing phase II. One project is in phase I and one is in phase II. In the first stage of preclinical pharmaceutical discovery, Medivir has some ten activities in explorative activities; the second, lead identification, encompasses three projects. The third stage, optimization, has one project, and two projects entering this phase. One project-MV026048-is in preclinical development, the stage closest to clinical development. For additional information on Medivir, please see; www.medivir.com Medivir Enquires Rein Piir, CFO/VP IR, Medivir +46 708 53 7292 Bo Öberg, VP R&D Strategic Planning, Medivir +46 708 98 6440 The Population Council The Population Council is an international, nonprofit institution that conducts research on three fronts: biomedical, social science, and public health. This research - and the information it produces - helps change the way people think about problems related to reproductive health and population growth. The Council's research makes a difference in people's lives. The Population Council has developed the three major reversible contraceptives; Copper IUDs, Norplant® and Mirena®. For additional information on Population Council, please see; www.popcouncil.org ------------------------------------------------------------ This information was brought to you by Waymaker http://www.waymaker.net The following files are available for download: http://www.waymaker.net/bitonline/2003/07/30/20030730BIT01300/wkr0001.doc http://www.waymaker.net/bitonline/2003/07/30/20030730BIT01300/wkr0002.pdf

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Medivir develops innovative drugs with a focus on cancer where the unmet medical needs are high. The company is investing in indication areas where available therapies are limited or missing and there are great opportunities to offer significant improvements to patients. Collaborations and partnerships are important parts of Medivir's business model and the drug development as well as the commercialization is conducted either by Medivir or in partnership. Medivir's share (ticker: MVIR) is listed on Nasdaq Stockholm's Small Cap list. www.medivir.com.

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