New clinical study shows that type 2 diabetics remain free of the disease if they lose weight and keep the weight down
On March 22, 2016, Newcastle University published a press release about a new study, which has shown that people who reverse their diabetes and then keep their weight down remain free of diabetes. In addition, the team found that patients who have had type 2 diabetes for up to 10 years can reverse their condition.
In the press release from Newcastle University, Roy Taylor, MD, FRCP, professor of medicine and metabolism at Newcastle University in the United Kingdom said:
“What we have shown is that it is possible to reverse your diabetes, even if you have had the condition for a long time, up to around 10 years. If you have had the diagnosis for longer than that, then don’t give up hope – major improvement in blood sugar control is possible.”
“The study also answered the question that people often ask me – if I lose the weight and keep the weight off, will I stay free of diabetes? The simple answer is yes!”
A previous study led by Professor Taylor, published in 2011, showed that diabetes could be reversed by a very low calorie diet. In this new study, 30 volunteers with type 2 diabetes followed a diet of 600 to 700 calories a day for 8 weeks. All oral agents or insulins were stopped at baseline. After 8 weeks, participants followed a stepped return to isocaloric diet through individualized weight maintenance program. Participants lost on average 14 kilograms. Over the next 6 months they did not regain any weight. The group included many people with longer duration diabetes, defined as more than 8 years and ranging up to 23 years. Overall, 12 patients who had had diabetes for less than 10 years reversed their condition. 6 months later they remained diabetes free. After 6 months, a thirteenth patient had reversed diabetes.
“This is highly encouraging data for type 2 diabetes patients. It demonstrates that many patients may potentially reverse their condition if they achieve a substantial weight loss through decreased food consumption and are able to keep the weight below the threshold for onset of type 2 diabetes. In March Saniona announced that it has obtained approval to initiate Phase 2a study for Tesomet in type 2 diabetes. Our vision for Tesomet is to develop a new type of treatment for diabetes, which can bring certain groups of patients in complete remission by contributing to a substantial weight loss through decreased food consumption,” says Jørgen Drejer, CEO of Saniona.
- Reverse your diabetes – and you can stay diabetes-free long-term. Newcastle University. Press Office, Press Release, published on March 22, 2016. http://www.ncl.ac.uk/press/news/2016/03/profroytaylordiabetesresearch/
- Very low calorie diet and 6 months of weight stability in Type 2 diabetes: Pathophysiologic changes in responders and non-responders. Sarah Steven, Keiren G Hollingsworth, Ahmad Al-Mrabeh, Leah Avery, Benjamin Aribisala, Muriel Caslake, Roy Taylor. Diabetes Care. Doi: 10.2337/dc15-9422
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Saniona is a research and development company focused on drugs for diseases of the central nervous system, autoimmune diseases, metabolic diseases and treatment of pain. The company has a significant portfolio of potential drug candidates at pre-clinical and clinical stage. The research is focused on ion channels, which makes up a unique protein class that enables and controls the passage of charged ions across cell membranes. Saniona has ongoing collaboration agreements with Upsher-Smith Laboratories, Inc., Productos Medix, S.A de S.V and Saniona’s Boston based spinout Ataxion Inc., which is financed by Atlas Venture Inc. and Biogen Idec Inc. Saniona is based in Copenhagen, Denmark, where it has a research center of high international standard. Saniona is listed at AktieTorget since April 2014 and has about 3,000 shareholders. The company’s share is traded under the ticker SANION. Read more at www.saniona.com.